Project Scientist Series hire in Cell Manufacturing University of California, Los Angeles, David Geffen School of Medicine - Hematology-Oncology United States

2018-2019 Parker Institute for Cancer Immunotherapy Center in Hem/Onc: Project Scientist Series hire in Cell Manufacturing

 

Job #JPF03848

  • DAVID GEFFEN SCHOOL OF MEDICINE - MEDICINE-HEMATOLOGY-ONCOLOGY

 

RECRUITMENT PERIOD

Open date: July 3rd, 2018
Last review date: July 17th, 2018
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: December 31st, 2018

Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
 

DESCRIPTION

The Parker Institute for Cancer Immunotherapy Center at UCLA is seeking a PhD-level project scientist to lead clinical cell manufacturing in support of clinical trials on adoptive T-cell therapy. Responsibilities will encompass GMP cell manufacturing, in vitro assays and in vivo studies in mouse xenograft models, regulatory documentation preparation, and communications with the FDA. The first clinical trial to be supported is expected to be led by Dr. Sarah Larson at the Hematology and Oncology Division and Dr. Yvonne Chen from the Department of Chemical and Biomolecular Engineering.

 

Qualifications:
• PhD degree in immunology, biomolecular engineering, molecular biology, or related disciplines (required)
• Experience with mammalian cell culture and sterile techniques (required)
• Experience with cGMP operating procedures and GMP facility (strongly preferred)
• Experience with flow cytometry and standard molecular biology techniques, including PCR, western blots, ELISA, and molecular cloning (required)
• Experience with mouse studies (strongly preferred)
• Strong oral and written communication skills (required)
• Meticulousness in establishing and following standard operating procedures (SOPs), maintaining detailed experimental records, and observing safety and sterility practices (required)

 

Responsibilities:
• Lead good manufacturing practice (GMP) cell manufacturing team in support of chimeric antigen receptor (CAR)-T cell therapy clinical trial. Tasks include but are not limited to: master GMP cell manufacturing, train laboratory assistants in GMP cell manufacturing, design and perform experiments related to the project, manage the progress of subgroup members, organize and lead subgroup meetings, mentor subgroup members and manage conflicts within the subgroup.
• Work with Dr. Larson and Prof. Chen to prepare the investigational new drug (IND) application and subsequently support a phase I clinical trial.
• Develop SOPs and manage the preparation of regulatory documentation related to GMP manufacturing in the IND application.
• Maintain communication with the FDA before, during, and after IND submission to ensure proper focus and progress on the project.
• Assist Dr. Larson and Prof. Chen in managing cell manufacturing related laboratory operations in general, including safety management.

 

JOB LOCATION

Los Angeles, CA

 

REQUIREMENTS

Document requirements
  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter (Optional)

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity - Statement addressing past and/or potential contributions to diversity through research, teaching, and/or service. 
    (Optional)

  • Misc / Additional (Optional)

 
Reference requirements
  • 3-5 required (contact information only)

 

HOW TO APPLY

  1. Create an ApplicantID

  2. Provide required information and documents

  3. If any, provide required reference information


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