Research Associate/Research Fellow in Translational Stem Cell Technology (Fixed-term) University of Nottingham, School of Medicine, Division of Cancer & Stem Cells United Kingdom

Research Associate/Research Fellow in Translational Stem Cell Technology (Fixed-term)


Reference
MED428918


Closing Date
Monday, 17th December 2018


Job Type
Research


Department
School of Medicine, Division of Cancer & Stem Cells


Salary
£27025 to £33199 per annum, (pro rata if applicable) depending on skills and experience (minimum £30395 with relevant PhD).


A position is open for a talented, proactive postdoctoral researchers to work on an exciting interdisciplinary project funded by the British Heart Foundation to address a workplan entitled, “Coupling gene targeted reporters with fully automated compound library screening to mature hPSC-cardiomyocytes”. The post will contribute to the final stages of a project that has been running since Jan 2015.

 

This post will be based in Nottingham but will collaborate extensively within the consortium, which includes Professor Andy Tinker & Dr Steve Harmer in London (for electrophysiology), Professor Peter Fischer in Nottingham (for compound library screening) and Professor Godfrey Smith in Glasgow (CellOPTIQ calcium imaging). The project is an extension of existing work in which cardiomyocytes from human pluripotent stem cells (hPSC) were engineered using CRISPR to express reporter constructs to detect maturation. A screen of ~30,000 compounds has identified 28 potential chemistries that are now being evaluated to determine what impact they have on hPSC-cardiomyocyte maturation. The project will combine stem cell technology and cardiomyocyte differentiation and robotics, with a particular emphasis on detailed cell phenotyping to quantify level of cardiomyocyte maturation.

 

The successful candidate for this post will have recently completed or hold a PhD in the biological sciences or equivalent. They will combine excellence in research, collaboration, communication and meeting deadlines. It is a particular need for the project that that candidate has a strong background expertise in cell phenotyping and an ability to learn rapidly new techniques with equipment they have not used previously. This may include, for example, skills in qPCR / RNA profiling, high content imaging (e.g. confocal plate reader), metabolism assays, and evaluation of calcium flux and/or contractility assays. Skills in human pluripotent stem cells and cardiomyocyte biology would be advantageous.

 

This full time post will be offered on a fixed-term contract, candidates must start by 4 February 2019 or within 2 weeks thereafter of this date. The end date will be 31 December 2019. Job share arrangements may be considered.

 

For an informal discussion, prospective candidates are invited to contact Professor Chris Denning, Tel 0115 82 31236, email chris.denning@nottingham.ac.uk.

 

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.


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