PhD student for multidisciplinary cancer research Ghent University, Department of Human Structure and Repair Belgium

PhD student for multidisciplinary cancer research


Last application date
Jan 30, 2019 23:59


Department
GE38 - Department of Human Structure and Repair


Contract
Limited duration


Degree
Master Degree in (Biomedical) Engineering, Pharmaceutical Sciences, (Bio)Medical sciences, or equivalent


Occupancy rate
100%


Vacancy Type
Research staff

 

Job description

The field of mechano-biology in cancer, which relates the biophysical and mechanical properties of human cancer tissue to its behavior and treatment response, is expanding rapidly. We are looking for a motivated PhD student for a multidisciplinary project in this field, funded by FWO-flanders and the Belgian Foundation against Cancer.

 

The aims of the project are:

  • to characterize the biophysical properties (stiffness, visco-elasticity, hydraulic conductivity) of the extracellular matrix in human cancer tissue;

  • to develop and validate a computational fluid dynamics (CFD) model to calculate interstitial fluid pressure and related parameters based on dynamic contrast enhanced (DCE)-MRI data;

  • and to validate the CFD model clinically, by correlating it with therapy response, invasive pressure measurements, in vitro biomechanical measurements, platinum drug penetration, and histological analyses in patients undergoing treatment.

 

The project is supervised jointly by the departments of Human Structure and Repair (prof Ceelen) and the department of Biomedical Engineering (prof Debbaut and prof Segers). In addition, close collaboration is foreseen with the INFINITY imaging lab (prof Van Hove), Experimental Cancer Research lab (prof De Wever), and the clinical departments of Ghent University Hospital. We offer an innovative project in a highly interdisciplinary research environment and within a young and dynamic team. The position is open immediately.

 

Profile of the candidate

  • Master degree in (Biomedical) Engineering, Physics, Pharmaceutical Sciences, (Bio)Medical sciences, or equivalent field

  • An adequate background/interest in mathematics and physics is required

  • Excellent oral and written proficiency in English

  • Highly motivated and team-oriented

  • You have a specific interest in and motivation for cancer research

 

How to apply

For more information and to apply, send your motivation letter, scientific CV, and references to prof Wim Ceelen by email (wim.ceelen@ugent.be).


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