Doctoral Student in Medical Science
University of Gothenburg
Sweden

MSCA-Doctoral student in Medical Science - Biomaterials-Cell biology

Diary id: PAR 2020/18
Employment level: Fixed term
Location: Institute of Clinical Sciences
Apply by: 2020-03-31

Job assignments

The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/languageId=100001

Project: Bone-anchored implants have been used clinically for decades. The healing is heavily dependent on the material properties, such as mechanical properties, surface roughness and topography as well as the surface chemistry. Biomechanical complication due to poor load transfer and mismatch in mechanical properties between implant material and host bone is known as “stress shielding”. The use of alloys with reduced elastic modulus have the potential to reduce the stress shielding by improving load distribution to the surrounding bone tissue. Another emerging clinical problem with implants is “biomaterial associated infection” and especially “biofilm formation on implant surfaces”. These biofilms are difficult to treat with conventional antibiotic treatments and novel strategies for avoiding bacterial colonization and biofilm formation is needed. Knowledge of the mechanisms whereby inflammatory cells and mesenchymal stem cells communicate is crucial for the understanding of cell differentiation, osteogenesis and bone remodeling in the bone-implant interface. The mechanisms whereby the different cells sense and communicate messages in the interface between tissue and material include a sequential release of chemokines, cytokines and growth factors. An important aspect of this project is to further understand the mechanisms whereby inflammatory cells and mesenchymal stem cells communicate signals at the implant surface, and how these communications are influenced by the surface properties as well as the presence of bacteria.
 
The aims are:
• To develop an in vitro system to evaluate the interplay between monocytes/macrophages and mesenchymal stem cells/pre-osteoblasts during the initial contact with metallic implant materials;
• To screen different compositions of metallic implant materials in the developed in vitro system in order to understand the role of alloying elements;
• To screen different surface modifications on the inflammatory response and the osteogenic effect;
• To explore the interaction between bacteria and monocytes/macrophages as well as bacteria and mesenchymal stem cells/pre-osteoblasts and the effect of different surface structures. 

The project involves in vitro cell culture, state of the art cellular and molecular techniques and a broad range of microscopy techniques to understand the cellular response. 

The project is part of BIOREMIA, an EU-financed Marie Sklodowska-Curie Initial Training Network. The principal objective of BIOREMIA is to set-up a new European education platform to train, guide and inspire 15 young researchers in the inter-sectoral exploration of innovative routes to counteract microbial biofilms on hard tissue- related implants by fabricating novel materials and surfaces. Information about the network is found at: http://www.bioremia.eu / 

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Employment

After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Fixed-term employment, 4 years. Extent: 100%. Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Biomaterials. First day of employment: as agreed. MSCA employment in a Marie Sklodowska Curie Program with MSCA financing (BIOREMIA - BIOfilm-REsistant Materials for hard tissue Implant Applications). 

Salaries for doctoral students are regulated in a local agreement at the University.

Additional information

In order to be approved for MSCA financing the applicant, at the time for the application, should not have resided in Sweden more than 12 months in the 3 years immediately prior to the reference date. Moreover the applicant must be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

For further information regarding the position

For more information about the project please contact:

Principal supervisor Anders Palmquist, Associate Professor, Institute of Clinical Sciences,
e-mail: anders.palmquist@biomaterials.gu.se

Assistant supervisor Margarita Trobos, Associate Professor, Institute of Clinical Sciences,
e-mail: margarita.trobos@biomaterials.gu.se 

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of  English 6 course or the acquired equivalent knowledge through previous studies

If your degree is from a university outside of Sweden, check what you need to submit at https://www.universityadmissions.se/en/All-you-need-to-know1/Applying-for-studies/Documenting-your-eligibility-for-studies/Instructions-for-Masters-applicants/Specific-requirements-for-my-country1/ where you can also see what you need to submit in order to fulfill the English language requirement.

  • If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

Closing date: 2020-03-31

 

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

 


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