Paediatric Research Assistant University of Oxford Department of Paediatrics United Kingdom

Paediatric Research Assistant

 

Department of Paediatrics, Le Gros Clark Building, South Parks Road, Oxford

 

Grade 6, £28,660 - £34,189 p.a.

Professor Matthew Wood’s laboratory – the pioneer in engineering extracellular vesicles (EVs) for delivering siRNA-based drugs to the brain – is looking for a highly motivated Research Assistant to join our Neuromuscular Disease group at Department of Paediatrics, University of Oxford.

The successful candidate will work on a Medical and Life Science Translational Funded project, ‘GAPDH and Extracellular vesicles: Biological nanoparticles for therapy of neurodegenerative diseases’. The project involves optimisation of novel technology developed recently in the lab for delivering RNA drugs to central nervous system of Huntington’s disease mouse model to silence mutant huntingtin gene. We are also investigating biogenesis of extracellular vesicles (EV) with major focus on role of GAPDH protein in secretion of EVs.

As a member of the Wood Group, you will work with a postdoctoral research scientist for day-to-day planning and execution of experiments such as engineering of EVs using molecular biology approach, purification of the EV-binding proteins from E. coli cells and presenting data at scientific meeting. Your responsibilities will include the establishment of stable cell lines for various EV protein markers by using lentiviral vectors, and isolation of EVs from different eukaryotic cell lines using our state of the art technology of EV purification by ultrafiltration and liquid chromatography. You will carry out collaborative projects with lab colleagues and partners at Cambridge and collaborate in the preparation of scientific reports and journal articles, and the presentation of papers and posters at conferences.

The ideal candidate will have an MSc in a relevant area of research such as cell biology, exosome biology, nanotechnology, gene transfer or molecular medicine; and will have experience in cellular transfections, confocal microscopy, flow cytometry and RNA and protein extraction for subsequent exosome characterisation by western blot and RT-qPCR. They will be able to communicate effectively with others, have an ability to work both independently and as part of a team, and have excellent organisational skills and the ability to keep meticulous records.

This is a full-time post offered for a fixed-term of 12 months in the first instance.

Only applications received before 12.00 noon on Monday 13 May 2019 will be considered. Interviews will be held as soon as possible thereafter.

 

Contact Person : Ghulam Dar                                     Vacancy ID : 140246

Contact Phone :                                                       Closing Date : 13-May-2019

Contact Email : ghulam.dar@paediatrics.ox.ac.uk


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