PhD Position on the Integration of Kinase – Phosphatase Signaling KU Leuven Laboratory of Biosignaling & Therapeutics Belgium

PHD POSITION ON THE INTEGRATION OF KINASE – PHOSPHATASE SIGNALING

 

The Laboratory of Biosignaling & Therapeutics, headed by Prof. Mathieu Bollen, has a long-standing interest in the regulation of proteins by reversible phosphorylation. A position is available for a motivated PhD student to explore how protein kinases and phosphatases work together to generate pulse-like signaling responses.

 

Project

Research project:

We have recently identified a biochemical timer that controls the mid-mitotic checkpoint.This timer stems from the integration of a counteracting kinase and phosphatase, and serves to activate the checkpoint before a sensor-dependent mechanism becomes operational. Our next goal is to explore whether other checkpoints associated with DNA replication and cell division are also governed by consecutive timer-sensor mechanisms, and to develop the therapeutic potential of such timers. The practical work will involve a combination of biochemistry, molecular biology and cell imaging.

 

References:

  • Qian et al., Mol. Cell 68 (2017), 715-730
  • Gelens et al., Trends Cell Biol. 28 (2018), 6-21
  • Qian et al., Bioessays, (2019), 41(3):e1800217. doi: 10.1002/bies.201800217

Profile

  • You have a good background in basic sciences.
  • You are willing to learn and adopt a variety of techniques of biochemistry, molecular biology and cell biology.
  • You have excellent oral and written communication skills, and have a good knowledge of English.
  • You aim for perfection and are practically skillful.
  • You are ambitious, inventive and have a long-term vision.
  • You are willing and capable to work as a team member.

Offer

  • We offer a doctoral position for 4-5 years in a stimulating scientific environment.
  • You will be registered in specific program of the doctoral school and will be able to attend the associated courses.
  • You will have access to state-of-the-art research facilities.
  • You will be guided on a daily basis by well-trained professionals and get a thorough training in scientific thinking, practice,presentation and writing.

 

Interested?

For more information please contact Prof. dr. Mathieu Bollen, tel.: +32 16 33 06 44, mail: mathieu.bollen@kuleuven.be.

To apply, please submit as soon as possible your motivation letter, CV, copies of transcripts/MSc degree, and names and contact information of at least two references.

You can apply for this job no later than July 31, 2019 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.


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