PostDoc and Ph.D. student in biology with computational background20.04.2023, Wissenschaftliches Personal To strengthen our team, we are recruiting a highly motivated PostDoc and Ph.D. student in biology with computational background About the lab The successful candidate will be part of the Andergassen lab based at the Institute of Pharmacology and Toxicology of the Technical University of Munich (TUM). The lab bridges computational (allele-specific epi-genomics) and experimental strategies (high-throughput bulk/single-cell sequencing, CRISPR in vivo editing) to understand the functional contributions of the non-coding genome, such as long non-coding RNAs on cardiovascular diseases (CVD). Furthermore, we aim to elucidate the contribution of sex chromosomes to sex differences in CVD. Particular attention is given to those genes that escape female X chromosome inactivation, resulting in a higher gene dose in females (XX) than males (XY). To systematically elucidate the molecular mechanisms for the CVD sex bias, the lab quantitatively assesses the impact of sex chromosomes and hormones by combining allele-specific genomics with disease and genetic mouse models. The lab aims to reveal relevant therapeutic candidates and new regulatory disease mechanisms forming the foundation of new sex-specific therapies for treating CVD in humans. More information: www.andergassenlab.com and https://www.professoren.tum.de/en/tum-junior-fellows/andergassen-daniel The Institute of Pharmacology and Toxicology (IPT) is part of the Medical Faculty of the Technical University of Munich (TUM), one of the leading universities in the European Union. The institute's research focuses on non-coding RNAs, their control of cardiac gene expression, and the effects of their therapeutic manipulation in cardiac disease. The institute's state-of-the-art research facility includes a fully equipped mouse cardiac phenotyping lab, a viral vector core, and the entire experimental pipeline for next-generation sequencing from tissue or single-cells, including FACS-based cell separation. Furthermore, the IPT coordinates and receives funding from the DFG Collaborative Research Center TRR267 "Non-coding RNA in the Cardiovascular System" and is the Munich partner site of the German Center for Cardiovascular Research (DZHK). The outstanding infrastructure and experience present in the institute provide an ideal environment for a project to succeed. More information: www.ipt.med.tum.de ● We are looking for a variety of academic backgrounds: molecular biology, biomedical research, bioinformatics ● 3-year contract with the possibility to prolong (payment according to TV-L E13) The TUM aims to increase the diversity of its staff substantially. As an equal opportunity and affirmative action employer, the TUM explicitly encourages nominations of and applications from women and all others who would bring additional diversity dimensions to the university's research and teaching strategies. Hinweis zum Datenschutz: Kontakt: daniel.andergassen@tum.de
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