Post Doc in Cell Metabolism in Skeletal Disorders and Bone Metastasis (Catholic University of Leuven )

The laboratory of professor Geert Carmeliet investigates the role of cell metabolism of skeletal cells in bone physiology and disorders, and the adaptations in tumor cell metabolism during bone metastasis. The lab is looking for a dynamic, highly motivated postdoctoral researcher to join the team. Our recent work shows that metabolism of skeletal cells regulates bone development and is crucial for bone regeneration (Stegen S, Cell Metab 2016; Stegen S, Nature 2019; van Gastel N, Nature 2020; Stegen S, Dev Cell 2020). Moreover, these studies reveal that targeting skeletal cell metabolism could be a possible therapeutic strategy to improve bone regeneration and to treat skeletal disorders such as osteoporosis and osteoarthritis. In addition, our data indicate that tumor cells that metastasize to bone are characterized by a specific metabolic profile. The current aim of the lab is to characterize in-depth (i) the role of cell metabolism of different skeletal cell types in skeletal disorders and (ii) the metabolic adaptations in tumor cells that regulate bone metastasis. The scientific approach combines advanced metabolic and (single-cell) transcriptomic analyses with state-of-the-art cell biological and molecular assays. The importance of the identified metabolic pathways will be validated by genetic or pharmacological approaches in vitro and in preclinical bone pathology models in mice. Responsibilities You will work independently on your project but in close collaboration with other team members using in vitro approaches and in vivo mouse models. Profile You have a PhD in biomedical sciences or bioengineering with focus on metabolism / skeletal tissue / regenerative medicine / (bone) metastases or related fields. You are skilled in molecular and cellular biology methods, biochemistry and cell culture. Knowledge of cell metabolism is a plus, but is not required. You are interested in working in a multidisciplinary environment, consisting of experts in biomedicine and engineering. You have a passion for science and are motivated to work on a highly innovative project in an open and dynamic team. You have excellent organizational skills and you can work in a team as well as independently. You should have good social and communicative skills and a solid knowledge of English. You have a proven publication record in international peer-reviewed journals. Offer A full-time 3-year position in a young and dynamic team. The opportunity to work in a mutlidisciplinary environment on exciting high impact projects. Access to state-of-the-art technologies and infrastructure. A dynamic working environment in which quality, professionalism and team spirit are highly valued. Excellent training conditions within a team of experts. Interested? For more information please contact Prof. dr. Geert Carmeliet, tel.: +32 16 33 07 31, mail: geert.carmeliet@kuleuven.be. Your application file should contain complete CV, motivation letter, list of publications, summary of past research and contact information or reference letter of 2 or 3 referees. The KU Leuven is very international, close to Brussels, at the heart of Europe. You can apply for this job no later than January 29, 2021 via the KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be. Employment percentage: Voltijds Location: Leuven Apply before: January 29, 2021 Tags: Chronische Ziekten en Metabolisme If you apply for this position please say you saw it on Medicinoxy

The laboratory of professor Geert Carmeliet investigates the role of cell metabolism of skeletal cells in bone physiology and disorders, and the adaptations in tumor cell metabolism during bone metastasis. The lab is looking for a dynamic, highly motivated postdoctoral researcher to join the team. Our recent work shows that metabolism of skeletal cells regulates bone development and is crucial for bone regeneration (Stegen S, Cell Metab 2016; Stegen S, Nature 2019; van Gastel N, Nature 2020; Stegen S, Dev Cell 2020). Moreover, these studies reveal that targeting skeletal cell metabolism could be a possible therapeutic strategy to improve bone regeneration and to treat skeletal disorders such as osteoporosis and osteoarthritis. In addition, our data indicate that tumor cells that metastasize to bone are characterized by a specific metabolic profile. The current aim of the lab is to characterize in-depth (i) the role of cell metabolism of different skeletal cell types in skeletal disorders and (ii) the metabolic adaptations in tumor cells that regulate bone metastasis. The scientific approach combines advanced metabolic and (single-cell) transcriptomic analyses with state-of-the-art cell biological and molecular assays. The importance of the identified metabolic pathways will be validated by genetic or pharmacological approaches in vitro and in preclinical bone pathology models in mice.

Responsibilities

You will work independently on your project but in close collaboration with other team members using in vitro approaches and in vivo mouse models.

Profile

You have a PhD in biomedical sciences or bioengineering with focus on metabolism / skeletal tissue / regenerative medicine / (bone) metastases or related fields.
You are skilled in molecular and cellular biology methods, biochemistry and cell culture. Knowledge of cell metabolism is a plus, but is not required.
You are interested in working in a multidisciplinary environment, consisting of experts in biomedicine and engineering.
You have a passion for science and are motivated to work on a highly innovative project in an open and dynamic team.
You have excellent organizational skills and you can work in a team as well as independently.
You should have good social and communicative skills and a solid knowledge of English.
You have a proven publication record in international peer-reviewed journals.

Offer

A full-time 3-year position in a young and dynamic team.
The opportunity to work in a mutlidisciplinary environment on exciting high impact projects.
Access to state-of-the-art technologies and infrastructure.
A dynamic working environment in which quality, professionalism and team spirit are highly valued.
Excellent training conditions within a team of experts.

Interested?

For more information please contact Prof. dr. Geert Carmeliet, tel.: +32 16 33 07 31, mail: geert.carmeliet@kuleuven.be.

Your application file should contain complete CV, motivation letter, list of publications, summary of past research and contact information or reference letter of 2 or 3 referees.

The KU Leuven is very international, close to Brussels, at the heart of Europe.

You can apply for this job no later than January 29, 2021 via the

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Employment percentage: Voltijds
Location: Leuven
Apply before: January 29, 2021
Tags: Chronische Ziekten en Metabolisme

If you apply for this position please say you saw it on Medicinoxy

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