Postdoc in Biological Sciences
University of Twente
Netherlands

Job description

Do helical stents induce swirling flow?

Background

Peripheral arterial disease (PAD) leads to the development of atherosclerotic plaques in the arteries. These may eventually cause stenosis or occlusion of the vessel, leading to intermittent claudication or critical limb ischemia, which severely impact quality of life and survival. Treatment often involves stent placement, but unfortunately the long-term outcome for endovascular treatment is still suboptimal, particularly in the femoropopliteal segment.

Veryan Medical has developed a stent graft (BioMimics 3D stent) for the superficial femoral artery that focuses on mimicking the native vessel geometry, which has a helical or non-planar shape. The helical shape promotes swirling flow, which in turn ensures high, protective, values of wall shear stress, thereby increasing the treatment durability.

However, there is a gap in the knowledge regarding the actual presence of swirling flow in-vivo. Therefore, the aim of the current project is to ultimately perform in-vivo blood flow quantification in patients, using high framerate contrast-enhanced ultrasound vector flow imaging (VFI) techniques. Prior to the in-vivo measurements we will determine the accuracy of and optimize our VFI technique for capturing swirling flow using in-vitro models. Ultimately, this knowledge will be used to design stents for other peripheral vascular beds with the potential to enable endovascular techniques, thereby providing a new treatment options to improve the quality of life, limb salvage and survival for PAD patients.

Job description

You will positioned in the Multi-Modality Medical Imaging group of the University of Twente. Here you will be part of a dynamic and multidisciplinary team. The project is supervised by prof. dr. Michel Reijnen and dr. Erik Groot Jebbink.

Your role in the project:

Perform measurements to understand how swirling flow can best be visualized using 2D ultrasound techniques
Develop an in vitro setup to compare the hemodynamics of the Biomimics 3D stent to regular straight nitinol stents in a controlled environment.
Perform a pilot study, including patients treated with the BioMimics stent to visualize if swirling blood flow is indeed induced.  This study will be performed in collaboration with the Rijnstate Hospital Arnhem.

Your profile

  • You have a PhD in biomedical imaging, and a demonstrated record or strong promise of research productivity
  • You have experience with medical ultrasound techniques
  • You have affinity for both in vitro measurements and working with data acquired in clinical (pilot) studies
  • You are skilled in working in a laboratory (e.g. building/modifying set-ups, running analyses)
  • You have strong analytical and conceptual skills
  • You have an excellent command of English and good communication skills.

Our offer

We offer you a very challenging position in an inspiring multidisciplinary environment. The University of Twente offers a dynamic ecosystem with enthusiastic colleagues in which internationalization is an important part of the strategic agenda.

  • We offer a 18 months fulltime post doc position.
  • We provide a stimulating, modern research environment with world-class research facilities
  • You will be part of a dedicated team with which you will collaborate extensively with industry.
  • The post-doc salary is between € 3.353,- and € 4.402,- gross per month depending on experience and qualifications.
  • An annual holiday allowance of 8% of the gross annual salary, and an annual year-end bonus of 8.3%.
  • A solid pension scheme.
  • Minimum of 29 leave days in case of full-time employment.
  • We provide excellent mentorship and a stimulating research environment to accelerate your further professional and personal growth.
  • The University of Twente is situated on a green and lively campus with lots of facilities for sports and other activities.

Information and application

For more information please contact Dr. Erik Groot Jebbink (e.grootjebbink@utwente.nl)

Your application must be uploaded via the link below. Do not apply by e-mail. Applications need to include a one-page motivation letter and a CV.

About the organization

TNW Faculty (Faculty of Science & Technology)

The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

As an employer, the TNW Faculty offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With our Faculty, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

University of Twente (UT)

University of Twente (UT) has entered the new decade with an ambitious, new vision, mission and strategy. As ‘the ultimate people-first university of technology' we are rapidly expanding on our High Tech Human Touch philosophy and the unique role it affords us in society. Everything we do is aimed at maximum impact on people, society and connections through the sustainable utilisation of science and technology. We want to contribute to the development of a fair, digital and sustainable society through our open, inclusive and entrepreneurial attitude. This attitude permeates everything we do and is present in every one of UT's departments and faculties. Building on our rich legacy in merging technical and social sciences, we focus on five distinguishing research domains: Improving healthcare by personalised technologies; Creating intelligent manufacturing systems; Shaping our world with smart materials; Engineering our digital society; and Engineering for a resilient world.

As an employer, University of Twente offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With us, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.


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