Postdoc in Translational Eye Research
University of Copenhagen Department of Drug Design and Pharmacology
Denmark

Postdoc in Translational Eye Research at the Department of Drug Design and Pharmacology

Faculty of Health and Medical Sciences
University of Copenhagen

We are looking for a highly motivated and dynamic researcher for a 3-year position to commence on 1 September 2020.

A 3-year position for a highly motivated and talented postdoctoral scientist is available in the lab of Professor in Translational Eye Research and Chief Physician Miriam Kolko. Most of the projects in the lab have a translational end and we use patient-derived models for preclinical studies. The candidate will have the opportunity to do both basic science and patient-near research as they work in a truly translational research environment. Preference will be given to candidates with expertise in cell culture models and functional readouts of mitochondrial deficiencies. Expertise in different omics techniques and the ability to participate in patient recruitment is an advantage, but not required. The successful candidate will primarily investigate the role of metabolic deficits and transcriptomic alterations in strictly characterized patients with neurodegenerative eye conditions and controls. Analyses will mainly be performed on primary fibroblasts and induced pluripotent stem cell (iPSC)-derived retinal cell lines.

Information on the department can be found at: https://drug.ku.dk/

Our research

Our research group, Eye Translational Eye Research, EyeTRU, focuses on translational research in neurodegenerative eye diseases. A special focus is on glaucoma. Glaucoma is one of the leading causes of blindness worldwide. Overall, glaucoma is defined by a progressive loss of the most inner retinal neurons, the retinal ganglion cells (RGC).

The aim of our research projects is to understand the cascade reactions leading to RGC death. In particular, we focus on models to study the interaction between RGC and their surrounding Müller glia. In this context, we elucidate how various forms of stress affect the ability of Müller glia to protect RGC. A special focus on energy metabolism and mitochondrial activity has recently been raised and by use of patient-derived tissue and cells, we are now further investigating the impact of mitochondrial dysfunction in patients with neurodegenerative eye conditions.

Over all, our research environment aims to bridge between basic scientist and medical doctors with a focus on glaucoma-related projects.

More information on our research can be found here:

  • Group website

Your job

We are looking for an outstanding and passionate scientist who has a strong background in cell biology. This post-doctoral project aims at understanding how metabolic and transcriptional changes affect RGCs and Müller glia, and how those can be linked to progressive retinal neurodegeneration as observed in Glaucoma. Your task will involve the establishment of patient primary fibroblast lines, reprogramming of such into hiPSC and functional analyses of both.

The project is funded by the Velux Foundation and involves close collaboration with Kristine Freude at the Department of Veterinary Sciences in regards to stem cell works as well as collaborations with Yonglun Luo at Aarhus University for bioinformatic analyses.

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in cellular biology or similar
  • You are experienced in culturing mammalian cells
  • You have an interest in neurodegenerative conditions, preferable neurodegenerative eye diseases
  • You are a team player and thrive to share knowledge
  • You are open minded and easy to approach
  • You have excellent English skills written and spoken

Desirable experience and skills:

  • Experience in running Seahorse experiments and other functional readouts of mitochondrial deficiencies
  • Experience in iPSC-models
  • Experience in bioinformatic analyses
  • Knowledge in clinical research and experience with patient recruitment

Place of employment

The place of employment is at the Department of Drug Design and Pharmacology, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories, cell culture, protein production, biophysical facilities.

Terms of employment

The employment as postdoc is a full time and fixed-term position for 3 years. Starting date is 1 September 2020 or as soon as possible hereafter.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,400 DKK/ approx. 4,610 Euro (April 2020-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 11 December 2019.

Questions

For further information please contact Miriam Kolko; miriamk@sund.ku.dk; https://drug.ku.dk/ 

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.

Application deadline:  31 May 2020, 23.59pm CET 

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in weeks 26 or 27

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Miriam Kolko
E-mail: miriamk@sund.ku.dk

Info

Application deadline: 31-05-2020
Employment start: 01-09-2020
Working hours: Full time
Department/Location: Department of Drug Design and Pharmacology


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