Faculty Mentor

• Daniel J. Rader, MD

Hiring Department

• Medicine - Division of Translational Medicine and Human Genetics

Funding Sources

• NIH grants
• AHA grants

Number of Positions

• 2

Eligibility

• U.S. citizens and foreign nationals may apply.

Description

Applications are invited for postdoctoral positions in the laboratory of Dr. Daniel J. Rader, Departments of Medicine and Genetics at the Perelman School of Medicine (PSOM) of the University of Pennsylvania.

The Rader lab is a multidisciplinary research environment focused on leveraging human gene discovery to elucidate the biology and molecular physiology of genes and pathways that influence plasma lipoprotein metabolism as well as the role of lipids in cardiometabolic traits and diseases (including atherosclerosis and metabolic dysfunction-associated steatotic liver disease or MASLD) and neurodegeneration/Alzheimer’s disease.

The lab integrates computational genomics, fundamental molecular investigation in cell and animal model systems, and targeted deep phenotyping in human subjects to establish molecular mechanisms, clinical relevance and accelerate translation of research insights to potential treatment of human cardiometabolic disorders.

Research Approaches

The research incorporates:

1. Computational multi-omics to identify genes and pathways of interest.
2. Human induced pluripotent stem cell (iPSC)-derived cell types to examine impact on hallmarks or biomarkers of phenotype and/or disease.
3. Mouse model systems including germline and somatic gene manipulation.
4. Use of natural genetic variants to elucidate protein structure-function relationships.
5. Recall-by-genotype studies in humans for deep phenotyping to inform genotype-phenotype relationships.

Preferred Research Backgrounds

We particularly encourage inquiries from:

• Bench scientists with some background in lipid metabolism.
• Dry lab scientists with experience in bioinformatics and high-throughput genomics, metabolomics and/or proteomics technologies.

Qualifications

Bench Scientists

• PhD in a biological science and a strong record of academic productivity are required.
• Excellent written and verbal communication skills are also required.
• Individuals should be able to demonstrate an ability to successfully complete projects independently.
• Applicants with experience in genetics/genomics, biochemistry, cell biology, or physiology, and/or cell and mouse models, are encouraged to apply.
• We are particularly interested in bench scientists with some background in lipid metabolism.

Dry Lab Scientists

• Ph.D. degree in Biostatistics, Computer Science, Bioinformatics, or other biomedical domain required.
• A strong record of academic productivity, excellent written and verbal communication skills are also required.
• Individuals should be able to demonstrate an ability to successfully complete projects independently.

Desirable Skills

• Fluency in statistical and data management computer languages such as:Experience in bioinformatics and high-throughput genomics, metabolomics and/or proteomics technologies.
  • R
  • Python
  • Bash
  • SQL

Application Instructions

To apply, please submit the following through Interfolio:

1. Brief statement of your research experience and interests detailing your qualifications for this position.
2. Curriculum Vitae (CV).
3. Name and contact information of three references.

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