Postdoctoral Research Assistant for Cancer Sciences
Queen Mary University of London Barts Cancer Institute
United Kingdom

Postdoctoral Research Assistant 

Department: Barts Cancer Institute
Salary: £34,220 - £40,194 per annum (Grade 4)
Reference: QMUL24486
Location: Charterhouse Square
Date posted: 01-Mar-2021
Closing date: 26-Mar-2021

Overview:

About the Role

Applications are sought for a Postdoctoral Research Assistants to undertake research into the development of viro-immunotherapy for pancreatic cancer under the supervision of Professor Yaohe Wang. The research will be based in the Centre for Cancer Biomarkers & Biotherapeutics at Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary, University of London.

About You

The appointee will develop an effective therapeutic regime using a novel viro-immunotherapeutic agent that was recently developed in our lab, together with combinations of chemotherapy and other immunotherapies. Essential requirements for this post include a PhD in cancer subject and an undergraduate degree in a biological subject. Significant research laboratory experience in virology, Immunology, viral vector construction, molecular biology and animal models is essential. Experience with some or all of the following would be an advantage: gene cloning, Western blotting, FACS, ELISA, CTL assay, IFN-γ ELISPOT assay and in vivo imaging. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential.

About the Project

The project will involve the evaluation of the combination of cytokine-armed oncolytic vaccinia virus with a PI-3kinase inhibitor and the chemotherapeutic agent gemcitabine as well as a-PDI in animal models. The project will require construction of new oncolytic viruses and the analysis of the biodistribution of the virus by molecular pathology and viral titre, as well as immunohistochemical and ELISA analysis of cytokine expression in a variety of tumour and normal organ tissues. Investigation of the efficacy of the therapeutic combination will be conducted in transgenic (KPC) mice and Syrian hamster tumour models of pancreatic cancer, with detailed immunophenotyping and molecular pathology.

About Queen Mary

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers.

We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.

Benefits

We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities including an on-site nursery at the Mile End campus.

The post is based at the Charterhouse Square Campus in London. It is full time, fixed term appointment for 18 months, with an expected start date of April 2021. The starting salary will be Grade 4, in the range of £34,220 - £40,194 per annum, inclusive of London Allowance.

Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.

Informal enquiries should be addressed to Yaohe Wang at yaohe.wang@qmul.ac.uk.

To apply for the role, please click the ‘apply’ button below.

The closing date for applications is 26th March 2021.

Interviews are expected to be held in the week commencing 4th April 2021.

The School of Medicine and Athena SWAN Charter for Women in Science.

The School of Medicine holds a Silver Athena SWAN Award.  We are committed to the equality of opportunities and to advancing women’s careers. We have policies to support staff returning from long-term absence, for flexible arrangements for staff with parental responsibilities and for childcare support. As part of the School’s commitment to the Athena SWAN principles we strongly encourage applications from women.

Valuing Diversity & Committed to Equality

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