Postdoctoral Research Fellow in Autoimflammatory Disorders
University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine
United Kingdom

Postdoctoral Research Fellow (Horizon)

Applications are invited for a Postdoctoral Research Fellow position in the research group of Professor Michael McDermott on a project funded by the Horizion 2020 entitled “Immunome project consortium for Autoimflammatory disorders (ImmunAID).

You will co-ordinate projects related to Work Package 3 (WP3) of ImmunAID programme entitled: “Inflammasome-associated pathways in sporadic and undiagnosed systemic autoinflammatory disorders”. More specifically you will be working on the task 1 and 2 of WP3 with the aims to:

  1. To characterise NLRP3 inflammasome particles and ASC specks, which may be associated with activation and release of inflammatory cytokines, in the serum of SAID patients.
  2. To investigate additional factors, such as anti-ASC antibodies (anti-ASC Ab), which may inappropriately prolong inflammasome activation.

Dr Sinisa Savic who is a grant co-holder with Prof McDermott will directly supervise these tasks. The work will be carried out in collaboration with Dr. Rained Doffinger, Department of Clinical Biochemistry and Immunology based at Addenbrooke’s Hospital, Cambridge.

Capitalising on the infrastructure and samples collected from concurrent studies at Leeds [the Centre for Systemic Autoinflammatory disorders (SAID) based in the Department of Clinical Immunology at St James’s University Hospital and the Academic Department of Rheumatology in Chapel Allerton Hospital] the post-holder will examine the status of inflammasome activation (NLRP3 and NLRC4, Pyrin initially) in cells and sera (blood) from patients with genetically defined SAID and also in those with sporadic or unknown cause.

The post-holder will work on developing assays to measure inflammasome particles in cell culture supernatants and biological fluids, mainly sera. Furthermore, the post-holder will, in collaboration with Dr Doffinger, work on developing assays for detection of novel autoantibodies, including anti-ASC antibodies, which potentiate the activity of the NLRP3 inflammasome. Lastly, we will have access to sera and cells from patients across the ImmunAID consortium (15 different centres across the EU), to validate the assays and help with development of relevant biomarkers.

The post-holder will support the management of the research group, specifically dedicated to this project, consisting of a Clinical Fellow, and one PhD student (in 2nd years), as required.

To explore the post further or for any enquiries you may have, please contact:

Dr Sinisa Savic, Associate Professor (Clinical)

Tel: +44 (0)113 2065567, Email:

OR

Professor Michael McDermott, Professor of Experimental Rheumatology

Tel + 44 (0) 113 343 8641, Email:

Further Information

The University of Leeds is committed to providing equal opportunities for all and offers a range of . The University is a charter member of Athena SWAN and holds the Bronze award. The School of Medicine holds the Gold award. We are committed to being an inclusive medical school that values all staff, and we are happy to consider job share applications and requests for flexible working arrangements from our employees.

Location: Other
Faculty/Service: Faculty of Medicine & Health
School/Institute: Leeds Institute of Rheumatic & Musculoskeletal Medicine (LIRMM)
Section: Section of Experimental Rheumatology
Category: Research
Grade: Grade 7
Salary: £33,797 to £40,322 p.a.
Working Time: 100% FTE
Post Type: Full Time
Contract Type: Fixed Term (for up to 28 Months or until April 2023, whichever is sooner)
Release Date: Friday 24 July 2020
Closing Date: Sunday 23 August 2020
Reference: MHLRM1135

 


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