Postdoctoral Research Fellow in Intestinal Immunity / Immunopathology
University of Bern Institute of Pathology
Switzerland

Postdoctoral Research Fellow in Intestinal Immunity / Immunopathology

In the Immunopathology Research Group, Division of Experimental Pathology, University of Bern, Switzerland, the position for a

Postdoctoral Research Fellow in Intestinal Immunity / Immunopathology

will become available by January 1, 2020 (negotiable) for at least 2 years to work on the cellular and molecular mechanisms regulating chronic relapsing – remitting inflammatory diseases in patients with Inflammatory Bowel Diseases (IBD) and in a new mouse model of chronic relapsing-remitting colitis (Brasseit et al., Mucosal Immunology 2016). Focus will be on the potential functional changes in the local myeloid cell compartment during different episodes of intestinal inflammation and remission, and on interventions to delay, or even prevent relapsing diseases.

The methodology required for the successful completion of the projects, including multi-color FACS analyses and sorting, single cell, and bulk RNA sequencing, but also in vitro assays (e.g. ELISA, chemotaxis assays, in vitro stimulation assays with intestinal bacteria). The projects are well advanced and the experimental systems are established. Our laboratory has a long-standing experience in the involvement of tissue resident T cells and macrophages in intestinal immunity, and more recently also in linking intestinal immunity with neurodegenerative disorders (Brasseit et al., Front Immunol, 2018, Yilmaz et al., Nat Med 2019; Liu et al., Nature Immunol 2019), Zysset et al., Nature Commun 2016).

The successful applicant is expected to have experience in multi-color flow cytometry, gene expression analyses (including basic knowledge of R script), and in handling mice would be an advantage.
The Department of Pathology at the University of Bern offers state-of-the art facilities in immunology, and pathology, including access to core facilities for flow cytometry, and confocal microscopy, and access to a germ-free and gnotobiotic mouse facility (see: www-pathology.unibe.ch.
The present project is salaried by a SNSF grant and will be carried out in close collaboration with the research groups of NGS platform (Professor Tosso Leeb), the Interfacultary Bioinformatics Unit, Bern (Dr. Irene Keller and Dr. Rémy Bruggmann), and the Swiss IBD Cohort Study (SIBDCS).

Applicants with a PhD or MD/PhD degree with experience in cellular and molecular immunology (mouse and/or human), documented by a corresponding list of publications, are kindly asked to submit by e-mail their application together with a curriculum vitae, a list of publications and the names and contacts of three possible referees in a single pdf file to Christa Hagert (christa.hagert@pathology.unibe.ch). The position will remain open until a suitable candidate will be recruited.
Contact person for further details:

Christoph Mueller, PhD
Professor of Experimental Pathology

E-Mail: christoph.mueller@pathology.unibe.ch.
Phone (direct): +41 31 632 8904


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