Postdoctoral Research Fellow In Spider Silk Protein BiochemistryKarolinska Institutet, NVS The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 450 employees and a revenue 2018 of 490 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.
Division and research group The research at the division of Neurogeriatrics is focused on neurodegenerative diseases, in particular Alzheimers disease and is strongly oriented towards translating findings from basic research into clinical practice.
The research group is located at Karolinska Institutet, campus Flemingsberg, and at SLU in Uppsala. We are currently five PhD students, two technicians, six post docs, two assistant professors, and two professors. We have developed the first biomimetic spinning method for production of artificial spider silk fibers. Now we aim to spin artificial silk fibers that match the native silk in terms of mechanical properties in a project that is funded by an ERC consolidator grant. To reach this goal we will use state-of -the art sequencing methods and protein engineering. We have recently published several articles in high ranked journals (Andersson et al. Nat Chem Biol. 2017; Kronqvist et al. Nat Commun. 2017; Rising&Johansson. Nat Chem Biol. 2015).
We now want to expand the group with a one year postdoc position with possiblility of extension.
The project and duties Spiders spin the toughest fiber known to man, but producing fibers that match the mechanical properties of the native fiber has been challenging. Furthermore, the relationships between protein primary structure, secondary structure content of the fiber and fiber mechanics are poorly understood. In this project we will generate an array of different artificial silk proteins and screen for candidates that express well in E.coli and that are water soluble. The soluble proteins will be characterized by commonly used spectroscopic methods and will be spun into fibers. The fibers will be subjected to secondary structure content analyses and tensile testing.
The successful candidate is expected to have a large interest in biotechnology and protein biochemistry and is expected to enjoy practical lab work and independently generate and analyze data. The applicant will supervise doctorial students and master students in the lab. We work in collaboration with other groups and very interdisciplinary, which demands the applicant to be independent, creative, have a positive attitude and be collaborative. The applicant is expected to work at both KI campuses as well as in Uppsala.
Entry requirements A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The applicant should have a doctoral degree in biotechnology, molecular biology, biomedicine or similar topic. The successful candidate is expected to have a strong drive to pursue research, be organized and structured and have an ambitious and innovative attitude. The project is cross-disciplinary and pursued in collaboration with several research groups, and good collaborative skills are necessary. Previous documented and extensive practical experience of cloning, expression in E.coli, protein purification and characterization is required. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write English is a requirement.
Application process An employment application must contain the following documents in English or Swedish:
A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)
The application is to be submitted through the Varbi recruitment system.
Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
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Type of employment Temporary position longer than 6 months Contract type Full time Number of positions 1 Working hours 100% City Huddinge County Stockholms län Country Sweden Reference number 2-2314/2019 Contact Anna Rising, Senior Researcher , + 46 (0) 70 410 69 97, anna.rising@ki.se Ulla Cronfalk-Hernlund, Head of Administration, + 46 8 524 868 18, ulla.cronfalk-hernlund@ki.se Maria Staiger, HR officer, + 46 8 524 837 79, maria.staiger@ki.se
Union representative Carina Eklund, OFR, 08-585 826 65, carina.eklund@ki.se Henry Wölling, SEKO, henry.wolling@ki.se Biborka Bereczky Veress, SACO, 46 70-173 85 75
Published 11.Apr.2019 Last application date 02.May.2019 11:59 PM CET
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