Postdoctoral Researcher in NK Cell Immunotherapy of Cancer
Karolinska Institute Department of Medicine
Sweden

Postdoctoral Researcher in NK Cell Immunotherapy of Cancer

Do you want to contribute to better health for all?

We are seeking a highly motivated and ambitious individual to join the research group of Yenan Bryceson as a Postdoctoral Fellow to translate insights to NK cell memory for cellular immunotherapy of cancer.

Previously considered an arm of the innate immune system, recent studies from our group (Schlums et al., Immunity 2015; Corat et al., Blood 2017; Schlums et al., Blood 2017; Holmes et al., Sci Immunol 2021) as well as others have uncovered and molecularly defined NK cell memory processes. A successful postdoctoral candidate will explore novel molecular aspects of human memory NK cell biology, derived from transcriptional and epigenetic analyses, and aim to translate findings for improved cellular products for immunotherapy. Methods will involve advanced flow cytometry and sorting, genome editing, cell culture and differentiation, transcriptional, epigenetic and functional analyses as well as xenogenic tumor models. The objective of this research is it to better understand NK cell-dependent immunological memory and potentially harness cellular differentiation pathways for cellular immunotherapy of cancer.

For more information about the group, please visit: Yenan Bryceson group

Your mission

You are expected to be a talented and enthusiastic researcher with a strong drive to perform basic research, playing an instrumental role in the elaboration of scientific hypothesis, experimental design, experimentation, data analysis and presentation/publication of results. You must be able to work within a team environment but retain enough independence to explore your results from a conceptual standpoint. You will be responsible for your own academic, research and administrative activities, adapt existing and develop new scientific techniques, test hypotheses and analyze data from a variety of sources.


Besides working on existing lab projects, postdocs are also encouraged to start their own new projects that can serve to launch their independent careers in science. Our aim is to provide a supportive environment conducive for development of independent scientists.

Your profile

Applications are invited from individuals of the highest calibre with a Ph.D. degree (2018 or later) in Immunology, Cell Biology, Hematopoiesis, ideally with proven skills in cellular immunology and/or haematopoiesis research. Excellent spoken and written English is a requirement. Applicants should have first author publications in recognized peer-reviewed journals.


The position requires experience with multiparameter flow cytometry, iPSC models and/or xenogenic mouse models. Experience with cell sorting, cell culture, genome editing, high-throughput sequencing, and bioinformatics is meriting. In addition, we believe that the successful candidate will have a strong background in immunology or hematopoiesis.

Good communication skills with the ability to present results clearly, work co-operatively as part of a team as well as independently with strong attention to detail are also essential. We will accord special weight to academic skills, particularly demonstrated excellence in research, a strong dedication, and excellent communication skills. Personal suitability is of great importance when evaluating the applicants.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

The Bryceson group is part of the Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine at the Karolinska Institute. The Department of Medicine at Huddinge comprises seven units, three research centers and, around 70 independent research groups. Our ambition is to be a leading department within medical research and education. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of hematopoiesis and immunity in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers within hematology and immunology in Europe. The laboratory offers an outstanding research environment for basic and translational research with a close association to the Hematology and Clinical Immunology Clinics at Karolinska University Hospital. For more information, please visit: HERM

Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Contact information of two references, recommendation letters are also welcome
  • A brief letter of motivation (no more than one page)
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

Welcome to apply at the latest 2021-04-26.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment According to agreement
Number of positions 1
Working hours 100%
City Flemingsberg
County Stockholms län
Country Sweden
Reference number STÖD 2-1573/2021
Contact
Yenan Bryceson, yenan.bryceson@ki.se
Union representative
Belinda Pannagel, SACO, Belinda.pannagel@ki.se
Elisabeth Henriksson, OFR, Elisabeth.henriksson@ki.se
Mari Gilljam, OFR, Mari.gilljam@ki.se
Published 26.Mar.2021
Last application date 26.Apr.2021 11:59 PM CET


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