Postdoctoral Position in Functional Proteomics University of Copenhagen Center for Basic Metabolic Research

Postdoctoral Position in Functional Proteomics (readvertisement) Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen We are looking for a highly motivated and dynamic postdoc with interest in proteomics and metabolism research to start as soon as possible. Background Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is a vibrant international research environment with a focus on interdisciplinary collaboration. Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life. You can read more about us here: www.cbmr.ku.dk. Our group and research The candidate will be part of the Functional Proteomics in Metabolism group (https://cbmr.ku.dk/research/integrative-metabolism-and-environmental-influences/deshmukh-group/) headed by Associate Professor Atul Deshmukh and work in close collaboration with the Novo Nordisk Foundation Center for Protein Research at University of Copenhagen. The successful candidate will work to integrate proteomics and functional physiology, to answer basic and applied research questions related to physical exercise, diet and metabolism. He or she will be embedded within CBMR and work in a scientific environment that bridges several disciplines of proteomics and metabolic diseases. Our facilities include state-of-the-art laboratories and core facilities and the position provides unique opportunity to advance expertise in state-of-the-art quantitative mass spectrometry, data analysis of large datasets and integration of matched large-scale datasets. Striving for academic excellence, collegial respect and freedom tempered by responsibility, we offer creative, friendly and stimulating working conditions in a dynamic and strong scientific environment where you get the opportunity to plan your work independently to further your professional and personal development. Project description MS-based proteomics allows for the investigation of protein dynamics by measuring multiple features such as expression, secretion, turnover rate, subcellular localization, interaction and post-translational modifications (PTMs). During the last 10 years, MS-based proteomics has progressed tremendously due to massive improvements in samples preparation workflows, liquid chromatography (LC) and MS instrumentation, as well as sophisticated algorithms for protein quantification. For the field of metabolism, MS-based proteomics offers a robust tool for investigation of diverse research questions. In human, metabolic processes are intimately intertwined with food intake as well as physical activity. Unfortunately, the majority of today’s population engages in less exercise and is becoming more sedentary. This coupled with increased consumption of a high-caloric diet, had led to an astonishing increase in the prevalence of obesity and type 2 diabetes. Physical exercise improves the detrimental effects of obesity, prevents or delays the onset of type 2 diabetes (T2D), and has other metabolically beneficial effects in both non-healthy and healthy individuals. Our understanding of how and why these diseases occur is incomplete, nor do we understand how physical activity improves and preserves overall metabolic health. We are seeking a highly motivated researcher who will apply state-of-the-art proteomics technology to investigate changes in protein dynamics with alterations in diet and/exercise, and describe their functional significance. He/she will combine a range of models (cell, rodent and human), and functional metabolic analyses with cutting-edge proteomics technology. Profile We are looking for a highly motivated and enthusiastic person with the following competencies and qualifications: Essential criteria PhD in biochemistry, chemistry, molecular biology, cell biology, or related science Hands-on experience using liquid chromatography and tandem mass spectrometry (LC-MS/MS) on Thermo Scientific instruments with standard software instrument control (Xcaliber) Knowledge concerning preparation of biological samples (e.g tissue, cells, plasma, serum) for MS-based proteomics Experience with quantitative analysis of peptides/proteins from biological material using nanoLC and MS-techniques (SRM, MRM) Ability to pursue and evaluate quantitative analysis and skills to analyze complete data sets using e.g. MaxQuant, Spectronaut, Skyline and other type of software for bioinformatics analysis Willingness to implement new relevant methods for proteomics analysis of biological samples Experience in Python, R or other programming language Proven track record showing continuous scientific productivity in peer reviewed journals Excellent written and oral communication skills in English Independent thinking and analytical aptitude for devising innovative scientific or technical solutions Demonstrate capacity for effective independent work and as part of a team Demonstrate enthusiasm, motivation, flexibility and confidence Desirable criteria Experience with isobaric labeling (preferentially TMT) Experience with enrichment of PTMs Previous experience in cell signaling pathways/network analysis Experience in experimental design, and planning of experiments Certified with FELASA laboratory animal science (or working towards certification) Candidates with additional background in metabolism, exercise physiology and the measurement of proteins and post-translational modifications within skeletal muscle would be highly regarded Terms of employment The postdoc position is a full-time position (37 hours per week) with a duration for 2 years. Starting date is as soon as possible. Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 11 December 2019. Questions For further information about the position, please contact Associate Professor Atul Deshmukh by e-mail: atul.deshmukh@sund.ku.dk. For questions regarding the recruitment procedure, please contact SUND HR CBMR at SUND-HR-CBMR@sund.ku.dk. International applicants may find these links useful: www.ism.ku.dk (International Staff Mobility) and https://www.workindenmark.dk/. Application procedure Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format: Motivated letter of application (max. one page) Curriculum vitae (maximum of 2 pages; your ORCID must be included) Full list of publications (journal impact factors at publication date must be included) References (name and contact details of at least two references) Application deadline: 30 July 2020 at 23.59 p.m. CET. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above mentioned requirements. The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether an unbiased assessor has passed their application for assessment. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/. The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. APPLY NOW Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career. Contact Atul Shahaji Deshmukh E-mail: atul.deshmukh@sund.ku.dk Info Application deadline: 30-07-2020 Employment start: Start as soon as possible Working hours: Full time Department/Location: Novo Nordisk Foundation Center for Basic Metabolic Research If you apply for this position please say you saw it on Medicinoxy Apply

Postdoctoral Position in Functional Proteomics (readvertisement)

Novo Nordisk Foundation Center for Basic Metabolic Research

University of Copenhagen

We are looking for a highly motivated and dynamic postdoc with interest in proteomics and metabolism research to start as soon as possible.

Background

Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is a vibrant international research environment with a focus on interdisciplinary collaboration. Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life.

You can read more about us here: www.cbmr.ku.dk.

Our group and research

The candidate will be part of the Functional Proteomics in Metabolism group (https://cbmr.ku.dk/research/integrative-metabolism-and-environmental-influences/deshmukh-group/) headed by Associate Professor Atul Deshmukh and work in close collaboration with the Novo Nordisk Foundation Center for Protein Research at University of Copenhagen.

The successful candidate will work to integrate proteomics and functional physiology, to answer basic and applied research questions related to physical exercise, diet and metabolism. He or she will be embedded within CBMR and work in a scientific environment that bridges several disciplines of proteomics and metabolic diseases.

Our facilities include state-of-the-art laboratories and core facilities and the position provides unique opportunity to advance expertise in state-of-the-art quantitative mass spectrometry, data analysis of large datasets and integration of matched large-scale datasets. Striving for academic excellence, collegial respect and freedom tempered by responsibility, we offer creative, friendly and stimulating working conditions in a dynamic and strong scientific environment where you get the opportunity to plan your work independently to further your professional and personal development.

Project description

MS-based proteomics allows for the investigation of protein dynamics by measuring multiple features such as expression, secretion, turnover rate, subcellular localization, interaction and post-translational modifications (PTMs). During the last 10 years, MS-based proteomics has progressed tremendously due to massive improvements in samples preparation workflows, liquid chromatography (LC) and MS instrumentation, as well as sophisticated algorithms for protein quantification. For the field of metabolism, MS-based proteomics offers a robust tool for investigation of diverse research questions. In human, metabolic processes are intimately intertwined with food intake as well as physical activity. Unfortunately, the majority of today’s population engages in less exercise and is becoming more sedentary. This coupled with increased consumption of a high-caloric diet, had led to an astonishing increase in the prevalence of obesity and type 2 diabetes. Physical exercise improves the detrimental effects of obesity, prevents or delays the onset of type 2 diabetes (T2D), and has other metabolically beneficial effects in both non-healthy and healthy individuals. Our understanding of how and why these diseases occur is incomplete, nor do we understand how physical activity improves and preserves overall metabolic health.

We are seeking a highly motivated researcher who will apply state-of-the-art proteomics technology to investigate changes in protein dynamics with alterations in diet and/exercise, and describe their functional significance. He/she will combine a range of models (cell, rodent and human), and functional metabolic analyses with cutting-edge proteomics technology.

Profile

We are looking for a highly motivated and enthusiastic person with the following competencies and qualifications:

Essential criteria

PhD in biochemistry, chemistry, molecular biology, cell biology, or related science
Hands-on experience using liquid chromatography and tandem mass spectrometry (LC-MS/MS) on Thermo Scientific instruments with standard software instrument control (Xcaliber)
Knowledge concerning preparation of biological samples (e.g tissue, cells, plasma, serum) for MS-based proteomics
Experience with quantitative analysis of peptides/proteins from biological material using nanoLC and MS-techniques (SRM, MRM)
Ability to pursue and evaluate quantitative analysis and skills to analyze complete data sets using e.g. MaxQuant, Spectronaut, Skyline and other type of software for bioinformatics analysis
Willingness to implement new relevant methods for proteomics analysis of biological samples
Experience in Python, R or other programming language
Proven track record showing continuous scientific productivity in peer reviewed journals
Excellent written and oral communication skills in English
Independent thinking and analytical aptitude for devising innovative scientific or technical solutions
Demonstrate capacity for effective independent work and as part of a team
Demonstrate enthusiasm, motivation, flexibility and confidence

Desirable criteria

Experience with isobaric labeling (preferentially TMT)
Experience with enrichment of PTMs
Previous experience in cell signaling pathways/network analysis
Experience in experimental design, and planning of experiments
Certified with FELASA laboratory animal science (or working towards certification)
Candidates with additional background in metabolism, exercise physiology and the measurement of proteins and post-translational modifications within skeletal muscle would be highly regarded

Terms of employment

The postdoc position is a full-time position (37 hours per week) with a duration for 2 years. Starting date is as soon as possible.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 11 December 2019.

Questions

For further information about the position, please contact Associate Professor Atul Deshmukh by e-mail: atul.deshmukh@sund.ku.dk.

For questions regarding the recruitment procedure, please contact SUND HR CBMR at SUND-HR-CBMR@sund.ku.dk.

International applicants may find these links useful: www.ism.ku.dk (International Staff Mobility) and https://www.workindenmark.dk/.

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below.
Furthermore, your application must include the following documents/attachments – all in PDF format:

Motivated letter of application (max. one page)
Curriculum vitae (maximum of 2 pages; your ORCID must be included)
Full list of publications (journal impact factors at publication date must be included)
References (name and contact details of at least two references)

Application deadline: 30 July 2020 at 23.59 p.m. CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above mentioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether an unbiased assessor has passed their application for assessment. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.