Research Associate in Synthetic Biology & Enzymology University of Manchester, Manchester Institute of Biotechnology

Closing date: 29/06/2016. Reference: EPS-08252. School: Manchester Institute of Biotechnology. Division: Synthetic Biology. Employment type: Fixed Term. Duration: From 01/07/2016 for 3 years. Location: Manchester. Salary: £30,738 to £37,738 per annum. Hours per week: Full time. Engineering New Enzymes and Pathways for the Biosynthesis of Antibiotics. This is an opportunity to work within the Manchester Institute of Biotechnology (MIB,http://www.mib.ac.uk), for three years starting from August 2016. The position is part of a large £3.2 million project funded by BBSRC / Innovate UK and led by Prof. Jason Micklefield in collaboration with GlaxoSmithKline and the John Innes Centre. The project aims to engineer new enzymes and biosynthetic pathways required for production of medically important antibiotics in Streptomyces host strains. New approaches will be developed for engineering non-ribosomal peptide synthetase (NRPS) enzymes, to create new assembly lines that can generate novel peptides. In addition to this, new tailoring enzymes will be evolved to derivatise the peptides. The new suite of enzymes will be introduced into an industrially optimised Streptomyces super-host strain to create new biosynthetic pathways that can deliver antibiotics which are urgently required to combat emerging antimicrobial resistance. You will join a large interdisciplinary team of biologists and chemists (see:http://www.manchester.ac.uk/research/jason.micklefield/research) and must hold a PhD, or have equivalent postdoctoral experience in molecular microbiology, microbial genetics, and / or molecular biology / biochemistry. The University of Manchester values a diverse workforce and welcomes applications from all sections of the community. Enquiries Professor Jason Micklefield, Professor of Chemical Biology Email: jason.micklefield@manchester.ac.uk +44 (0)161 306 4509 Date of external posting Friday 27 May 2016 This vacancy will close for applications at midnight on the closing date. Further particulars *Further particulars including job description and person specification are available on the University of Manchester website - click on the 'Apply' button below to find out more.* If you apply for this position please say you saw it on Medicinoxy

Closing date: 29/06/2016.
Reference: EPS-08252.
School: Manchester Institute of Biotechnology.
Division: Synthetic Biology.
Employment type: Fixed Term.
Duration: From 01/07/2016 for 3 years.
Location: Manchester.
Salary: £30,738 to £37,738 per annum.
Hours per week: Full time.

Engineering New Enzymes and Pathways for the Biosynthesis of Antibiotics.

This is an opportunity to work within the Manchester Institute of Biotechnology (MIB,http://www.mib.ac.uk), for three years starting from August 2016.

The position is part of a large £3.2 million project funded by BBSRC / Innovate UK and led by Prof. Jason Micklefield in collaboration with GlaxoSmithKline and the John Innes Centre.

The project aims to engineer new enzymes and biosynthetic pathways required for production of medically important antibiotics in Streptomyces host strains.

New approaches will be developed for engineering non-ribosomal peptide synthetase (NRPS) enzymes, to create new assembly lines that can generate novel peptides.

In addition to this, new tailoring enzymes will be evolved to derivatise the peptides. The new suite of enzymes will be introduced into an industrially optimised Streptomyces super-host strain to create new biosynthetic pathways that can deliver antibiotics which are urgently required to combat emerging antimicrobial resistance.

You will join a large interdisciplinary team of biologists and chemists (see:http://www.manchester.ac.uk/research/jason.micklefield/research) and must hold a PhD, or have equivalent postdoctoral experience in molecular microbiology, microbial genetics, and / or molecular biology / biochemistry.

The University of Manchester values a diverse workforce and welcomes applications from all sections of the community.

Enquiries

Professor Jason Micklefield, Professor of Chemical Biology

Email: jason.micklefield@manchester.ac.uk

+44 (0)161 306 4509

Date of external posting Friday 27 May 2016

This vacancy will close for applications at midnight on the closing date.

Further particulars

Further particulars including job description and person specification are available on the University of Manchester website - click on the 'Apply' button below to find out more.

If you apply for this position please say you saw it on Medicinoxy