Project Scientist in Pediatrics Hematology / Oncology
University of California Los Angeles David Geffen School of Medicine
United States

Pediatrics Hematology/Oncology - Project Scientist series

Job #JPF05878
  • David Geffen School Of Medicin - PEDIATRICS-ADMINISTRATION

Recruitment Period

Open date: September 14th, 2020

Next review date: Friday, Oct 16, 2020 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.

Final date: Wednesday, Jun 30, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Description

The Division of Hematology-Oncology in the Department of Pediatrics of the David Geffen School of Medicine at UCLA is seeking a Project Scientist. The appointment will be in the Project Scientist series; academic rank will be commensurate with experience.
This position requires a Ph.D. or equivalent and prior experience. This is a Non-Senate position.

  1. (Manufacturing products for clinical research according to Good Manufacturing Practice (GMP) guidelines
  2. Operate in a GMP regulated environment according current standard operating protocols
  3. Meticulous record keeping and maintenance of GMP, GTP and basic research related records and documents.
  4. Attend and arrange seminars, training sessions and workshops to maintain competency in evolving current GMP/GTP regulations
  5. Performing post-manufacturing lot-release tests: Elisa, Colony-forming Unit (CFU) assay, ELISA, Endotoxin assay, Mycoplasma assay, vector copy number (VCN) test by ddPCR
  6. Culture of hematopoietic progenitor cells for in vitro differentiation into T-cells for proof of principle testing of gene delivery
  7. Conduct experiments for FDA IND application(s)
  8. Conduct DNA, RNA and protein isolation and purification according current GLP research grade protocols
  9. Quantification of nucleic acids and proteins
  10. Perform PCR and qPCR
  11. Perform multiparametric flow cytometry to assist on-going specific NYESO-TCR research project for intracellular, surface and peptide target markers.
  12. Culture adhered and non-adherent mammalian cells, preparing media, aliquots and other compounds utilized in tissue culture with proper sterile aseptic technique.
  13. Ability to set up co-cultures for killing-assays or peptide release production-analysis
  14. Ability to set up experiments utilizing real time in vitro cell imaging system Incucyte
  15. Perform ELISA experiments in either cellular supernatants or cellular lysates normalizing results against total protein content
  16. Plasmid preparation, bacteria growth on competent E. coli or Stable 3 systems, positive transformants selection and sequences analysis
  17. Ability of align sequences on APE-software (or-equivalent) and design plasmids for plasmid-vector construction and PCR analysis
  18. Perform plasmid sequencing and re-sequencing
  19. Production of high-titer viral vectors, purification and concentration of viral supernatants for retrovirus
  20. Production of high-titer viral vectors, purification and concentration of viral supernatants for lentivirus
  21. Determination of viral titer by ddPCR on fresh and frozen supernatants
  22. Document results of experiments and elaboration of reports for NYESO-TCR team leader
  23. Perform experiments associated to survival tittering and transduction efficiency on target cells
  24. Design and re-design of viral vectors for large scale manufacture of GMP and GMP-comparable clinical grade virus.
  25. Performs other job-related duties as assigned

Interested applicants may apply through this link: https://recruit.apo.ucla.edu/JPF05878

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see:
UC Nondiscrimination and Affirmative Action Policy http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct.

Job location

Los Angeles, CA

Requirements

Document requirements
  • Curriculum Vitae - Your most recently updated C.V.
  • Cover Letter (Optional)
  • Statement of Research (Optional)
  • Statement of Teaching (Optional)
  • Statement on Contributions to Equity, Diversity, and Inclusion - An EDI Statement describes a faculty candidate’s past, present, and future (planned) contributions to equity, diversity, and inclusion. To learn more about how UCLA thinks about contributions to equity, diversity, and inclusion, please review our Sample Guidance for Candidates and related EDI Statement FAQ document.
  • Misc / Additional (Optional)
Reference requirements
  • 3-5 letters of reference required
 


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