Research Assistant / Associate in Medical Research
University of Cambridge
United Kingdom

The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy and offers excellent opportunities for postdoctoral development. The Unit is part of the University of Cambridge; it is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in November 2020.

We are looking to appoint a Research Assistant /Research Associate to work in the Laboratory of Mitochondria and cell death regulation following toxic injury:

https://www.mrc-tox.cam.ac.uk/research/l-m-martins-programme

We are seeking a highly-motivated postdoctoral candidate, to join Miguel Martins's lab. Our work employs Drosophila as a model organism to better understand the consequences of mitochondrial dysfunction for the activation of adverse outcome pathways that lead to cellular and tissue damage. We employ multi-disciplinary approaches, including Drosophila genetics, quantitative fly behaviour analysis, RNAseq, metabolomics, quantitative proteomics, and microbiome analysis. We model how drug exposure and mitochondrial liabilities activate adverse outcome pathways. These adverse outcome pathways, in turn lead to cellular and tissue dysfunction.

Job description

This project offers an exciting opportunity to study how mitochondrial toxicity can modify immune responses.

The successful candidate will explore the links of how drug exposure, through off-target effects, can cause mitochondrial defects and activate innate immunity as an adverse outcome pathway of toxicity. The working hypothesis that forms the basis of this project is that mitochondrial dysfunction acts in a non-cell autonomous manner to induce cell death through inter-organ communication. The organs that are the focus of this study are the brain, fat body and intestine.

Key Lab Publications:

Garrido-Maraver, J. et al. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease", Biology Open (2020)

Garrido-Maraver, J.et al. Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin, Cell Death and Disease (2019)

Celardo, I.et al. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective, Cell Death and Differentiation (2017)

Celardo, I.et al. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease, Cell Death and Disease (2016)

Requejo-Aguilar, R.et al. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nature Communications 5, 1-9 (2014)

Tufi, R.et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nature Cell Biology (2014)

Applicants must hold, or be close to completing a Ph.D., in a relevant discipline such as Neurobiology, Cell Biology or Immunology along with experience in biochemical techniques (protein expression/purification, western blotting, ELISA assays) and imaging techniques (electron or fluorescence microscopy). Submission of at least one first author peer-reviewed paper is expected.

Appointment at Research Associate level is dependent on having a Ph.D. Those who have submitted but not yet received their Ph.D. will be appointed at Research Assistant level, which will be amended to Research Associate once the Ph.D. has been awarded.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are invited and can be directed to Miguel Martins at lm795@mrc-tox.cam.ac.uk . If you have any queries regarding the application process please contact Rebecca Heatherley at rsh49@mrc-tox.cam.ac.uk .

Please quote reference PU23332 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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