Research Assistant in Immunology and Inflammation
Imperial College London Department of Immunology and Inflammation
United Kingdom

Job summary

Applications are invited for a Research Assistant in the Haemostasis Group at Imperial College London. The aim of the project, being led by Dr James Crawley, Dr Isabelle Salles-Crawley and Dr Josefin Ahnström, is to further understand the molecular basis of the TFPI-Protein S anticoagulant pathway and develop novel strategies for safer anticoagulation in individuals at increased risk of thrombosis. Further information about the Haemostasis...

Job listing information

  • Reference MED01771
  • Date posted 2 March 2020
  • Closing date 2 April 2020


Key information about the role

  •  
    Location Hammersmith Campus (map)
  • Position type Full time, fixed term
  • Salary £35,477 – £38,566 plus benefits
  • Department Department of Immunology and Inflammation
  • Category Researcher / Non Clinical Researcher


Job description

Job summary

Applications are invited for a Research Assistant in the Haemostasis Group at Imperial College London. The aim of the project, being led by Dr James Crawley, Dr Isabelle Salles-Crawley and Dr Josefin Ahnström, is to further understand the molecular basis of the TFPI-Protein S anticoagulant pathway and develop novel strategies for safer anticoagulation in individuals at increased risk of thrombosis. Further information about the Haemostasis Group research can be found at: http://www1.imperial.ac.uk/departmentofmedicine/divisions/experimentalmedicine/haematology/coag/

Cardiovascular diseases remain the major cause of mortality in the developed world. The use of antiplatelet agents (e.g. aspirin, P2Y12 antagonists) or anticoagulants (e.g. heparin, warfarin, direct oral anticoagulants, DOACs) is effective at reducing mortality / morbidity, as well as the incidence of subsequent thrombotic events. However, such therapies are not optimal and are also associated with elevated risk of bleeding. The TFPI anticoagulant pathway inhibits the initiation of coagulation and is essential for the coordinated regulation of haemostasis. TFPI is highly dependent upon its cofactor, protein S. Our laboratory has contributed to the understanding of the molecular mechanisms associated with these proteins in the regulation of haemostasis. In this British Heart Foundation funded programme grant, we aim to develop new assays to characterise TFPI / protein S function, to evaluate their anticoagulant properties in vivo, and to develop novel therapeutics that target this pathway that may provide improved protection against thrombotic disorders.

Duties and responsibilities

You will use a range of molecular and cell biology techniques, PCR-based genotyping, cell culture, protein expression/purification during the course of this project. You will provide support to two post-doctoral researchers working on this programme. You will be part of a well-established and internationally renowned laboratory funded primarily by the British Heart Foundation.

Essential requirements

We are looking for a highly motivated researcher with strong research experience in biological sciences. You will hold a BSc / MSc or equivalent. Experience in molecular and cell biology, cell culture and antibody production are highly desirable, although training will be provided. You will also have excellent communication skills, the ability to solve problems, and the ability to work both on your own initiative and as a member of a team.

Further information

This is a full-time, fixed term post until 14thSeptember 2022. You will be based at the Hammersmith Campus (East Acton).

Should you require any further details on the role please contact Professor Jim Crawley -  j.crawley@imperial.ac.uk

For technical issues when applying online please email recruitment@imperial.ac.uk


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