Research Assistant in Non-Viral Vector Development for Gene Delivery to the Lung
Imperial College London National Heart and Lung Institute
United Kingdom

Job summary

Applications are invited for a Research Assistant in non-viral vector development for gene delivery to the lung. The post compliments a wider programme of research which aims to develop emerging RNA therapeutics including mRNA and siRNA for respiratory disease. You will assist in the synthesis of polymeric, or lipid-based biomaterials for nanoformulation, perform characterisation of polymer and nanoparticle properties, and evaluate their...

Job listing information

  • Reference MED02014
  • Date posted 15 September 2020
  • Closing date 18 October 2020

Key information about the role

  • Location Hammersmith Campus (map)
  • Position type Full time, fixed term
  • Salary £35,477 – £38,566 plus benefits
  • Department National Heart & Lung Institute
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

Applications are invited for a Research Assistant in non-viral vector development for gene delivery to the lung. The post compliments a wider programme of research which aims to develop emerging RNA therapeutics including mRNA and siRNA for respiratory disease.

You will assist in the synthesis of polymeric, or lipid-based biomaterials for nanoformulation, perform characterisation of polymer and nanoparticle properties, and evaluate their potential as gene delivery vectors. You will use established methods to synthesise biodegradable polymers but will also have the flexibility to incorporate novel ligands to investigate the influence of polymer modification on transfection efficiency in lung cells. The post provides an exciting opportunity to work at the intersection of materials science and nanomedicine.

You will join a dynamic environment in Dr Patel’s group based within the Inflammation, Repair and Development section which consists of clinicians and basic scientists striving to improve health outcomes for patients with respiratory disease. You will have access to state-of-the-art facilities within the National Heart and Lung Institute. The Patel group places emphasis on personal development and support will be offered to candidates who wish to apply for research fellowships or develop their professional skills over the course of their employment.

Duties and responsibilities

Your duties will include polymer/biomaterials synthesis, formulation of non-viral vectors, materials and nanoparticle characterisation, cell culture, in vitro gene transfection. You will also maintain accurate and complete records of experimental work, apply scientific rigour at all times to ensure validity and reproducibility of data and actively participate in the research programme of the Group and effectively communicate with team members.

Essential requirements

You will have a master’s degree related to chemistry, gene delivery, pharmacy, materials science, bioengineering or other relevant discipline is essential. You will also have previous wet lab experience in a research laboratory related to chemistry or biomaterials development, experience conducting materials characterisation assays such as nuclear magnetic resonance and dynamic light scattering and some cell culture experience. Undergraduate training in chemistry, materials science or other related field is also essential. You will also possess the ability to work well within a multidisciplinary team, have excellent problem-solving skills and be a motivated and dedicated researcher.

Further information

The post can be full time for 9 months or part time (0.75 FTE) for 12 months and fixed term in the first instance. 

Should you require any further details on the role please contact: Dr Asha Patel (asha.patel@imperial.ac.uk).

For technical issues when applying online please email recruitment@imperial.ac.uk.

Committed to equality and valuing diversity, we are an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/ 


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