Research Associate in Cancer Research
University of Cambridge
United Kingdom

The Brenton (https://www.cruk.cam.ac.uk/research-groups/brenton-group) and Halim labs (https://www.cruk.cam.ac.uk/research-groups/halim-group) are jointly recruiting a highly talented, ambitious and motivated scientist to join our vibrant and collaborative ovarian cancer and tumour immunology groups within the University of Cambridge, CRUK Cambridge Institute. This post is specifically created to advance a new collaborative project that explores the role of innate immunity in the metastatic spread of ovarian cancer. We are interested in understanding the interplay between different innate lymphoid cells, and subsequent adaptive immune responses, in controlling cancer metastasis. This builds on recent findings in the Halim group that innate lymphoid cells can modulate anti-metastatic immunity (Nature Immunology 2020), or regulatory T cells (Immunity 2018). Concurrently, the Brenton lab has recently demonstrated how mutational signatures annotate new high-grade ovarian carcinoma subtypes and define clinically relevant mutational processes (Nature Genetics 2018). We wish to test specific hypotheses reflecting the interplay between these mutational processes, chromosomal instability and immunological response. This post benefits from access to exclusive immunological reagents, advanced mouse models of ovarian cancer, and direct clinical input in our respective research groups. Our long-term goal is to dissect the immunological mechanisms that regulate the host response to metastasis in ovarian cancer, and to explore their potential as novel therapies.

As a postdoctoral researcher, you will drive your research project and establish novel in vivo and in vitro models to assess the function of immune cells in cancer, as well as study signalling pathways and downstream mechanisms using cutting edge genomic and metabolomic approaches. You will join a collaborative and highly motivated team of researchers in a top ranked university and research institute. Our groups are further supported by world-leading core facilities (https://www.cruk.cam.ac.uk/core-facilities) which researchers are encouraged to utilize to their fullest potential. The CRUK Cancer Centre Ovarian programme runs cross-disciplinary journal clubs and scientific meetings to provide further training in the translational science of ovarian cancer.

Candidates should be proficient in animal (mouse) experimental procedures, isolation and phenotyping of cell subsets using flow cytometry, gene expression analysis (RNA-seq, scRNA-seq), IF microscopy and cell culture. Ideally, you have demonstrated creative and independent work in your area of expertise. A strong background in molecular and/or cancer biology, immune and/or cancer metabolism, as well as bioinformatics will be highly valued.

Applicants who wish to be considered must display the ability to undertake project management, method development, data collection and analysis. You must have excellent communication and organizational skills, the ability to develop innovative experimental approaches to answer research questions, and thrive both in independent research and while working collaboratively as part of a team.

The successful candidate must have (or be about to receive) a PhD in immunology.

About Cancer Research UK, Cambridge Institute Europe's top cancer charity, Cancer Research UK, has teamed with the University of Cambridge to create the world class Cambridge Institute (CI) situated on the Addenbrooke's Biomedical Campus in Cambridge. The Halim lab has several ongoing clinical collaborations with Papworth and Addenbrooke's hospitals.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The Institute's research ranges from basic cancer biology through translational research to clinical application. The Institute currently houses over 350 researchers and contains new state-of-the-art research facilities. (http://www.cruk.cam.ac.uk/).

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

The closing date for applications is 5 October 2020.

Interview Date: TBC.

Please quote reference SW23726 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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