Research Associate in Cancer Research
Imperial College London Institute of Cancer Research
United Kingdom

 

Job summary

The Cancer Research UK (CRUK) Accelerator Award is a multi-institutional consortium led by Professor Paul French at Imperial College, with core partners: the Francis Crick Institute (Crick), the Institute of Cancer Research (ICR), the IRB in Barcelona and the University of Edinburgh. The Award will develop automated imaging for 3D cancer models, including patient-derived organoids (PDO), to accelerating our ability to understand and...

Job listing information

  • Reference MED01781
  • Date posted 10 March 2020
  • Closing date 9 April 2020

Key information about the role

  • Location Hammersmith Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department Department of Surgery & Cancer
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

The Cancer Research UK (CRUK) Accelerator Award is a multi-institutional consortium led by Professor Paul French at Imperial College, with core partners: the Francis Crick Institute (Crick), the Institute of Cancer Research (ICR), the IRB in Barcelona and the University of Edinburgh. The Award will develop automated imaging for 3D cancer models, including patient-derived organoids (PDO), to accelerating our ability to understand and therapeutically target complexity and heterogeneity in cancer. This programme has four interlinked objectives and deliverables:

  • Establishment of reproducible cell culture models through the development of standard operating procedures for cell culture and cell manipulation
  • Development of automated high content analysis microscopes to allow the matching of the right imaging capability to address the research question under investigation
  • Development of software tools for image classification, tackling problems of processing speed and data volumes
  • Development of robust and reproducible cell culture assays to investigate changes in cancer phenotypes at a single cell level in 3D

To deliver the objectives, the consortium brings together expertise in high content image analysis, cancer cell biology, drug discovery and software development, to deliver open source microscopes and software, standardised protocols for cell culture and assay development.

Duties and responsibilities

As the core Research Associate, you will play a critical role in co-ordinating, curating and sharing the practical cancer cell biology aspects of the research across the consortium. This will include developing, optimising and curating know-how, methodologies protocols and standard operating procedures (SOP) to culture, label, assay and analyse 3D cell cultures (including PDO) across the Accelerator consortium. While you will predominantly work in London at Imperial the Crick and the ICR, you will work closely with colleagues at Edinburgh and Barcelona, which may include visits to their laboratories. You will develop specific 3D cell cultures and exemplar assays, particularly using the new Accelerator instrumentation, and will help colleagues at partner sites to implement and optimise assays of 3D cancer models. You will also help analyse the (3D image) data from such assays, including the evaluation and refinement of new image processing tools. You will provide support and training to research staff and PhD students associated with the Accelerator project and to external collaborators where approved by the Accelerator Steering Committee.

Essential requirements

    • Hold or be about to obtain a PhD, or equivalent level of professional qualifications and experience, in a cancer biology related field
    • Proven research experience in developing and using 3D cell cultures and organoids
    • Proven research experience in preparing samples for microscopy, including genetic and other labelling techniques
    • Proven research experience in microscopy image analysis
    • Knowledge of Cancer biology and drug discovery as well as 3D cell culture techniques and challenges

Further information

This post is offered on a full-time, fixed term basis until 28thFebruary 2024.

Imperial College is supportive of flexible working and will be happy to discuss the possibility of implementing such arrangements for this post, with suitably qualified people subject to operational requirements.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

Should you require any further details on the role please contact: Prof. Iain McNeish - i.mcneish@imperial.ac.uk

For technical issues when applying online please email: recruitment@imperial.ac.uk


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