Research Associate in Immunology and Inflammation
Imperial College London Department of Immunology and Inflammation
United Kingdom

Job summary

We invite applications for an exciting role as Research Associate in the Centre for Inflammatory Diseases at Imperial College London. We are looking for a post-doctoral analyst to join a team of researchers working on using –omic approaches to study immunological diseases in the research group of Dr James Peters. Dr Peters is a Reader in Immunology and Inflammation and has dual training in both clinical medicine and computational biology /...

Job listing information

  • Reference MED02308
  • Date posted 24 February 2021
  • Closing date 24 March 2021

Key information about the role

  • Location Hammersmith Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £48,340 plus benefits
  • Department Department of Immunology and Inflammation
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We invite applications for an exciting role as Research Associate in the Centre for Inflammatory Diseases at Imperial College London. We are looking for a post-doctoral analyst to join a team of researchers working on using –omic approaches to study immunological diseases in the research group of Dr James Peters. Dr Peters is a Reader in Immunology and Inflammation and has dual training in both clinical medicine and computational biology / genomics.

The post will focus on integrating high-dimensional genomic, transcriptomic and proteomic data to better understand autoimmune diseases, particularly systemic lupus erythematous (SLE, or ‘lupus’), vasculitis and COVID-19. These diseases exhibit considerable heterogeneity in their clinical manifestations, response to drug treatments and long-term outcomes. However, the molecular basis for this remains unknown.

This post will provide excellent opportunities for collaboration with leading scientists at other institutes. These may include the Wellcome Trust Sanger Institute (Dr Emma Davenport), the University of Leeds (Prof Ann Morgan and Prof Jenny Barrett), Kings College London (Prof Tim Vyse), Monash University (Prof Eric Morand) and the University of Cambridge Cardiovascular Epidemiology Unit (Dr Adam Butterworth, Dr Mike Inouye). Dr Peters is part of the Health Data Research UK (HDR UK) London network.

Dr Peters has a strong track record in -omics studies, and it is expected that the work will lead to high-impact scientific publications (see ‘Selected References’ below).

Selected References

Gisby J, Clarke C, Medjeral-Thomas N, et al., Peters JE, Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease, Medrxiv 2020. https://www.medrxiv.org/content/10.1101/2020.11.05.20223289v1 

Lyons PA*, Peters JE*, Alberici F*, Liley J*, Coulson RMR, et al. Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status. Nature Communications: in press. Preprint on BioRxiv: https://www.biorxiv.org/content/early/2018/12/10/491837 

Sun BB*, Maranville JC*, Peters JE*, Stacey D, Staley JR, et al. Genomic atlas of the human plasma proteome. Nature 2018; 558:73-79.

Peters JE, Lyons PA, Lee JC, Richard AC, Newcombe PJ, Richardson S, Smith KGC. Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune- mediated disease. PLoS Genetics 2016; 12:e1005908.

Duties and responsibilities

You will be a key member of a multi-disciplinary team of scientists (including both clinical and non-clinical, and ‘wet’ and ‘dry’ lab researchers). Your role will involve conducting analysis of high-dimensional multi-omic datasets, including genomic, transcriptomic and proteomic data, and correlating this against clinical variables. You will be involved in the design of –omic experiments and help develop detailed analysis plans, as well as contribute to the group’s overall strategy. This work is likely to lead to exciting publications, and you will have the opportunity to present your work at national and international conferences. You will also have the opportunity to assist with supervising PhD students.

You will work on analysing in-house –omic datasets, generated on blood and tissues from patients and healthy controls, as well as publicly available datasets (eg GWAS summary statistics).

Approaches may include: single-cell RNA-seq analysis, clustering and supervised learning on transcriptomic and proteomic data, GWAS, polygenic risk scores, quantitative trait locus mapping and Mendelian randomisation.

Please note that is a ‘dry lab’ position. Although you will be involved in experimental design and studying planning, your role will not involve sample processing or any other laboratory work.

Essential requirements

    • You will have a passion for and experience of multi-omic data analytics to better understand human health and disease.
    • You should have, or be due to imminently submit, a PhD in the field of human genomics / statistical genetics / genetic epidemiology or similar.
    • You will be joining a collaborative research environment, and so will need good interpersonal and communication skills.
    • You will need be able to work both as part of a team and independently.

For the full essential requirements see the Person Specification in the Job Description

Further information

This post is available on a full time and fixed term basis for 2 years in the first instance.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 - £39,183 per annum.

Should you require any further details on the role please contact: James Peters, j.peters@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


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