Research Associate in Immunology and Inflammation
Imperial College London Department of Immunology and Inflammation
United Kingdom

Job summary

We invite applications for an exciting role as Research Associate in the Centre for Inflammatory Disease at Imperial College London. We are seeking a dynamic post-doctoral analyst to join a team of researchers working on using –omic approaches to study autoimmune diseases in the research group of Dr James Peters. Dr Peters is a Reader in Immunology and Inflammation and has dual training in both clinical medicine and computational...

Job listing information

  • Reference MED01557
  • Date posted 6 November 2019
  • Closing date 4 December 2019

Key information about the role

  •  
    Location Hammersmith Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department Department of Immunology and Inflammation
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

 

We invite applications for an exciting role as Research Associate in the Centre for Inflammatory Disease at Imperial College London. We are seeking a dynamic post-doctoral analyst to join a team of researchers working on using –omic approaches to study autoimmune diseases in the research group of Dr James Peters. Dr Peters is a Reader in Immunology and Inflammation and has dual training in both clinical medicine and computational biology/genomics.


You will be involved in working as part of a multi-disciplinary team of scientists (including both clinical and non-clinical, and ‘wet’ and ‘dry’ lab researchers).

Duties and responsibilities

You will focus on integrating high-dimensional genomic, transcriptomic and proteomic data to better understand autoimmune diseases, particularly systemic lupus erythematous (SLE, or ‘lupus’) and vasculitis. These diseases exhibit considerable heterogeneity in their clinical manifestations, response to drug treatments and long-term outcomes. However, the molecular basis for this remains unknown.

You will work on analysing in-house omic datasets, generated on blood and tissues from patients and healthy controls, as well as publicly available datasets (e.g. GWAS summary statistics).

Approaches may include: single-cell RNA-seq analysis, clustering and supervised learning on transcriptomic and proteomic data, GWAS, polygenic risk scores, quantitative trait locus mapping and Mendelian randomisation.

Dr Peters has a strong track record in -omics studies, and it is expected that the work will lead to high-impact scientific publications.

You will be provided excellent opportunities for collaboration with leading scientists at other institutes. These may include the Wellcome Trust Sanger Institute (Dr Emma Davenport), the University of Leeds (Prof Ann Morgan and Prof Jenny Barrett), Kings College London (Prof Tim Vyse), Monash University (Prof Eric Morand) and the University of Cambridge Cardiovascular Epidemiology Unit (Dr Adam Butterworth, Dr Mike Inouye). Dr Peters is part of the Health Data Research UK (HDR UK) London network.

Please note that is a ‘dry lab’ position. Although you will be involved in experimental design and studying planning, you will not be involved in sample processing or any other laboratory work. If you have a biological background you are welcome to apply but need to demonstrate sufficient quantitative experience and commitment to a full-time analytical role.

You will be a key member of a multi-disciplinary team of scientists. Your role will involve conducting analysis of high-dimensional multi-omic datasets, including transcriptomic and proteomic data, and correlating this against clinical variables. You will be involved in the design of –omic experiments and help develop detailed analysis plans, as well as contribute to the group’s overall strategy. This work is likely to lead to exciting publications, and you will have the opportunity to present your work at national and international conferences. You will also have the opportunity to assist with supervising PhD students.

Essential requirements

You be will be suitable if you are a highly ambitious individual with a PhD in cancer cell biology or cancer metabolism (or a closely related area) who has experience in a range of relevant cell and molecular biology techniques. You will be a particularly strong candidate if you have experience with (single cell) RNA-seq and/or lentiviral shRNA/CRISPR-Cas9 based approaches. Previous experience with metabolic studies and a good understanding of key aspects of cancer cell biology is highly desirable. A keenness to explore innovative multidisciplinary approaches and the ability to communicate with other research teams is equally welcome.

Further information

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

The role is full-time and fixed-term for 3 years in the first instance.

Should you require any further details on the role please contact: James Peters -  j.peters@imperial.ac.uk.

For technical issues when applying online please email recruitment@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

Documents

  • JD and PS - Research Associate.pdf


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