Research Associate in Infectious Disease
Imperial College London Department of Infectious Disease
United Kingdom

Job summary

We are looking to recruit a passionate and self-motivated postdoctoral Research Associate to join Dr. Dominguez-Villar’s laboratory at Imperial College London, UK. Our research focuses on understanding the molecular mechanisms that maintain human regulatory T cell identity and plasticity and the regulation of CD4+ T cell responses in autoimmune and infectious disease settings. We have recently defined key signalling pathways underlying human...

Job listing information

  • Reference MED02392
  • Date posted 22 April 2021
  • Closing date 23 May 2021

Key information about the role

  • Location St Mary's Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £48,340 plus benefits
  • Department Department of Infectious Disease
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are looking to recruit a passionate and self-motivated postdoctoral Research Associate to join Dr. Dominguez-Villar’s laboratory at Imperial College London, UK. Our research focuses on understanding the molecular mechanisms that maintain human regulatory T cell identity and plasticity and the regulation of CD4+ T cell responses in autoimmune and infectious disease settings.

We have recently defined key signalling pathways underlying human Treg plasticity and acquisition of a Th1-like effector phenotype (Nat Immunol 2018;19:665, Cell Mol Life Sci 2017;74:4059, EMBO Rep 2016;17:1169). You will examine the role of specific signalling pathways in maintaining Treg identity and modulating plasticity, and the role of environmental factors in activating / inhibiting them, with application to autoimmune diseases. This is a highly translational research project that will involve human samples from healthy individuals and patients, and might involve in vivo models of autoimmunity.

Duties and responsibilities

You will be responsible for designing, performing and analysing experiments, and share findings with coleagues. You will help supervise students as needed. You will be responsible for identifying and optimizing new techniques for the collection and analysis of data. You will write reports for submission to funding agencies, and manuscripts for submission to peer-review journals.

Support will be provided to prepare applications to postdoctoral or career transition fellowships if desired.

Essential requirements

You will have a strong human molecular immunology background and experience in human immunology-related techniques. Flow cytometry, culture of primary T cells and Tregs, as well as molecular biology techniques are essential skills for applicants to be considered. Bioinformatic skills are desired but not required.

You should hold a PhD in molecular or cellular immunology with experience in human immunology and have knowledge of statistical analysis of data. You should be willing to work as part of a team, to collaborate and help other colleagues when necessary.

Further information

This role is available on a full time and fixed term basis for 1 year, with the potential for extension.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 - £39,183 per annum.

Should you require any further details on the role please contact Dr. Margarita Dominguez-Villar (m.dominguez-villar@imperial.ac.uk).

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/


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