Research Associate in Medical Research
University of Cambridge
United Kingdom

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https://www.stemcells.cam.ac.uk/).

The WTKLAB (https://www.wtklab.com/) uses multidisciplinary approaches to understand epithelial cell fate decisions during normal development and early stages of tumourigenesis (Bach et al 2017, Lazarus et 2018, Hadi et al 2020 and Bach and Pensa et al 2021). The lab is based at Department of Pharmacology and the Wellcome-MRC Stem Cell Institute. One area we will be focusing on in the next 5 years, is how does the whole tissue respond to acquiring oncogenic mutations? and what is the role of the cell of origin and the stroma/immune microenvironment in shaping the developmental trajectory of the cell of origin to a malignant tumour? To achieve this the lab is recruiting two post-doctoral scientists to drive the expansion of this area in the lab. The post holders will use state of the art genetically engineered mouse models (GEMM), proteomics and single cell genomics to investigate and perturb cellular changes occurring during early stages of epithelial transformation.

Requirements:

We are looking for candidates who hold a PhD in the field of epithelial stem cells, genomics, cancer biology and cell biology/developmental biology. The post holders will have demonstrable (eg. first author publication) and extensive experience in one or more of the following areas:

  • Designing, performing and analysing single cell genomics experiments and or other NGS techniques.
  • Designing, performing and analysing GEMM experiments.
  • Designing, performing and analysing lineage tracing experiments.
  • Designing, performing and analysing organoid experiment.
  • Solid background in molecular and cell biology techniques.

It's essential that the post-holders are organised, responsible, able to work collaboratively as a member of a team and can communicate effectively and clearly both orally and in writing. The successful candidates are expected to take a lead role in the laboratory including supervision of research assistants and students. Proven capacity to design, execute, and interpret your own experiments is essential.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 25th April 2021

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager

Please quote reference PS25983 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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