Research Associate in Metabolic Science
University of Cambridge Institute of Metabolic Science
United Kingdom

A Postdoctoral Research Associate position is available within the group of Professors Fiona Gribble and Frank Reimann at the Institute of Metabolic Science (IMS), focussing on the gut-brain-pancreatic axis and its role in the control of insulin secretion and food intake. The group has a particular interest in developing gut peptide based strategies for treating type 2 diabetes and obesity. Supported by the Wellcome Trust, this post will involve the use of patch clamp electrophysiology to study nutrient sensing pathways in human enteroendocrine cells using genetically modified intestinal organoid cultures.

Key responsibilities:

Scientists with substantial experience in patch clamp electrophysiology, particularly of endocrine cell types, are encouraged to apply. Applicants should have a background in studying the gut-brain-pancreatic axis or related metabolic physiology. The role holder will be responsible for running their own electrophysiology research projects and will also provide electrophysiological support and training for other members of the group.

  • Perform patch clamp electrophysiological recordings of fluorescently-labelled endocrine cells in intestinal organoid cultures
  • Maintain organoid cultures
  • Genetically modify organoids e.g. to label new cell types or generate knockout lines by CRISPR-Cas9
  • Perform Ca2+ imaging, flow cytometry, single cell RNAseq, and other techniques according to the direction of the project and candidate's interests
  • Present research work and data within the Institute, nationally and internationally and prepare and submit research for publication in peer-reviewed journals
  • Assist in providing instruction to postgraduate students and other members of the research group in electrophysiology techniques
  • Assist the Principal Investigators in preparing manuscripts and applications to funding bodies

Informal enquiries are welcomed and should be directed to:

Prof Frank Reimann E: fr222@cam.ac.uk T: 01223746796

Or

Prof. Fiona Gribble E: fmg23@cam.ac.uk T: 01223336746

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 5 May 2021

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference RG26249 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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