Research Associate in Neurodegenerative Diseases
University of Cambridge
United Kingdom

Applications are invited for a postdoctoral research associate to join a project aimed at repairing the diseased or injured central nervous system, focusing on the visual system.

Neurodegenerative diseases such as glaucoma cause irreversible damage to neurons in the retina and optic nerve, leading to a loss of vision. The team, led by Dr Richard Eva and Professors Keith Martin and James Fawcett at the University of Cambridge, John van Geest Centre for Brain Repair, have identified a number of new strategies for stimulating regeneration in the optic nerve.

The position, funded by the UK blindness charity Fight for Sight will focus on Protrudin and related molecules as targets for stimulating guided regeneration through the diseased or injured nerve.

Axon regeneration through the optic nerve and on towards the visual centres of the brain will be necessary as a regenerative treatment for glaucoma, and also after retinal ganglion cell or eye transplantation. Protrudin is a scaffolding molecule that localizes to axon growth tips and brings together many of the components needed for axon growth including recycling endosomes, motor proteins and the endoplasmic reticulum.

The work is part of a large project to repair the injured central nervous system by stimulating the transport of regenerative machinery into axons in the optic nerve or spinal cord. The group is studying the role of various sub-cellular organelles during axon growth and regeneration, using a number of models of axonal injury.

The successful applicant will have expertise in animal models of disease or injury, and is not necessarily required to have a background in eye or neuro -biology, although this would be preferred. Education to PhD level is required.

The project will be closely related to our recent publications in Nature Communications and EMBO Molecular Medicine:

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS https://www.nature.com/articles/s41467-020-19436-y

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS. https://www.embopress.org/doi/full/10.15252/emmm.201911674

For questions relating to the post, please contact Dr. Richard Eva or Professor James Fawcett at re263@cam.ac.uk or jf108@cam.ac.uk

Fixed-term: The funds for this post are available for 31 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role.

The closing date for applications is 14 April 2021, with the interview date TBC.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference ZE26046 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


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