Research Associate in New Transgenic Mouse Model
University of Cambridge
United Kingdom

We are looking for a motivated, ambitious and independent post-doctoral researcher to join the group of Professor Maria Grazia Spillantini at Cambridge University, to investigate in a new transgenic mouse model, the progression of alpha-synuclein pathology from gut to brain as a primary mechanism of pathology and as a target for novel therapies for Parkinson's Disease.

The positions are funded by a grant from the the Aligning Science Across Parkinson's (ASAP) partnering with The Michael J. Fox Foundation for Parkinson's of which Prof John Hardy at UCL is the principle investigator. The work will be done in collaborations with groups at UCL, Oxford University and Royal Veterinary College and will be seeking to understand why Parkinson's progresses and spreads through the brain at a variable rate.

The work will involve pharmacological in vivo treatments and mouse behavior as well as methods such as immunohistochemistry, protein chemistry, proteomics, transcriptomics, single cell analysis. The successful candidates will work in close contact with the collaborators in the grant and will interact with other national and international groups holding ASAP grants.

Key Requirements:

The Applicant should already have a PhD degree at the moment of the application in order to be considered. Prior experience in in vivo studies with animal models of neurodegenerative diseases is required and holding of a Home Office Animal Licence will be a great advantage. Experience in immunohistochemistry, molecular biology, protein chemistry, pharmacological treatments and behavioral studies in mice, is desirable as well as knowledge of microscopy techniques. The postdoctoral fellow will present results at group meetings, meetings of the ASAP grants network, at scientific conferences, and will prepare reports and manuscripts.

For questions relating to the post, please contact Maria Grazia Spillantini at

Fixed-term: The funds for this post are available until 31 December 2023 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 30th March 2021

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference ZE25911 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

If you apply for this position please say you saw it on Medicinoxy


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