Research Associate in Physiology of Mutagenesis
University of Cambridge Cambridge Biomedical Research
United Kingdom

The Physiology of Mutagenesis group led by Dr Serena Nik Zainal is based on the Cambridge Biomedical Research Campus as part of the MRC Cancer Unit and the Academic Department of Medical Genetics: . We are seeking a capable data analyst/bioinformatician to join our team at an exciting time in the area of whole cancer genomics and mutagenesis.

Beyond the usual driver mutations that are sought in cancer genomics, detailed downstream analyses of all mutations present in cancers reveal mutational signatures that are the final outcome of combinations of DNA damage and DNA repair processes. Our team was involved in the initial conception of the field and latterly have pioneered experimental validation and development of novel clinical tools.

In the Physiology of Mutagenesis group, you will explore the aetiologies of mutational signatures, the mechanisms by which they arise and are embedded in the genome and develop new tools for clinical application. The role will involve data exploration of large cancer datasets and developing, testing and improving current algorithms for patient classification.

The post-holder shall have a PhD in genomics/computational biology/cancer biology and have an analytical track record preferably in genomics. Experience of NGS data processing is essential, with experience in whole genome sequencing data analysis being desirable. The post-holder shall have a high intensity period of pushing already-developed models to completion and be aiming for applying for post-doctoral fellowships or other senior bioinformatic positions. The post-holder shall have a strong track record of self-motivated scientific pursuit and be familiar with working in a high-performance compute environment, with an understanding of the sensitivities of working with clinical data. Experience of mutational signatures is desirable.

Fixed-term: The funds for this post are available until 31 May 2023 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

The salary will be on the scale £32,816 to £40,322 pa depending on relevant postdoctoral experience.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter outlining your suitability for the role, CV and contact details for two academic referees in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Closing date for applications is 13 December 2020 Interview on week commencing w/c 14 December 2020

Please quote reference SK24742 on your application and in any correspondence about this vacancy. Applications received after the deadline may be considered at the discretion of the assessing panel.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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