Research Fellow in Proteostasis
Monash University Australian Regenerative Medicine Institute
Australia

Research Fellow (Proteostasis)

Job No.: 615356

Location: Clayton campus

Employment Type: Full-time

Duration: 12-month fixed-term appointment

Remuneration: $69,401 - $94,190 pa Level A (plus 9.5% employer superannuation)

  • Be inspired, every day
  • Drive your own learning at one of the world’s top 80 universities
  • Take your career in exciting, rewarding directions

Everyone needs a platform to launch a satisfying career. At Monash, we give you the space and support to take your career in all kinds of exciting new directions. You’ll have access to quality research, infrastructure and learning facilities, opportunities to collaborate internationally, as well as the grants you’ll need to publish your work. We’re a university full of energetic and enthusiastic minds, driven to challenge what’s expected, expand what we know, and learn from other inspiring, empowering thinkers.

The Opportunity

The Group of Dr Nadinath B. Nillegoda at the Australian Regenerative Medicine Institute, Monash University is seeking a dedicated and passionate Research Fellow (Postdoctoral Fellow) interested in a) characterizing regulatory elements of protein disaggregases using biochemical and biophysical approaches, and b) developing small molecules that could activate these molecular machines and act as a new class of anti-neurodegenerative drugs - a first in the field.

The overarching research themes in the Nillegoda laboratory involve proteostasis, cell repair, molecular chaperones and protein conformational disorders in humans. 

Brief project background: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are often characterized by the formation and persistence of protein aggregates (amyloids) in neuronal tissue that initiate the disease process by a gain-of-toxicity mechanism. Despite global efforts to bolster dementia research, there are currently no effective treatments or cures. Our ground-breaking research uncovered the primary protein aggregate solubilizing machine (disaggregase) constituted by the Heat shock protein 70 (Hsp70) chaperone system in human cells. This discovery introduced a previously unacknowledged metazoan cellular repair activity fundamentally important for decreasing cellular aggregate levels and the associated cytotoxicities linked to neurodegeneration.

We are seeking a highly motivated and talented individual with a doctoral qualification or progress towards a doctoral qualification in cellular protein quality control systems, molecular chaperones, and proteostasis. Applicants with knowledge and experience in proteostasis, cellular protein quality control pathways, protein folding and molecular chaperones, protein aggregation and cellular stress pathways and/or protein degradation will be given preference.

A strong track record of publications directly linked to proteostasis and/or characterization of proteins using cutting edge biochemical and biophysical techniques in peer-reviewed journals is a must. Required techniques/methods include  extensive experience in biochemical and biophysical techniques including protein purification methods, characterization, labelling, enzyme kinetics, and protein interactions (FRET- and anisotropy-based) is a must. Additionally, the candidate should be competent in basic molecular biology techniques such as vector design and molecular cloning, PCR methods, western blotting and immunoprecipitation. Having experience in mammalian cell culture, genetic modification of cells (stable cell lines; CRISPR-Cas9 gene editing; designing), immunohistochemistry, fluorescence/confocal microscopy and image processing are an advantage.  

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. For instructions on how to apply, please refer to "How to apply for Monash Jobs".

Enquiries

Dr Nadinath Nillegoda, Group Leader, +61 3 9905 3636 

Position Description

Download File Research Fellow (Proteostasis)

Closing Date

Wednesday 31 March 2021, 11:55pm AEDT


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